Dear Sir or Madam,

This is Yuhong Zha from the Kihara Bioinformatics Laboratory. We are currently developing a Chimera extension to implement our MAINMAST algorithm. However, we encountered a problem of using Chimera's command line "rc("save current_session.py")" to save current session. This problem only happens in some Mac system.

In our extension, we want to save the whole session after open some files. So we first do "os.chdir(path)" to where we want to store the file. Then we use "rc("save current_session.py")" to save the current session info to a file. However, after we changed the current working directory correctly, "rc("save current_session.py")" still fails and displays error message of "Directory () does not exists". I have attached the code and error we encounter. I checked the current working directory right before calling "rc("save current_session.py)" and I am sure the current working directory is correct and is not (). Is there any settings we missed that result in rc(command) only execute at directory ()? Or is there any way that we can specify which directory we want to save the session using rc(command)?

We tried it on 2 Mac but only one of them has this problem. I am thinking maybe some preference setup would cause this problem?

Also, we encountered a problem of "Access Denied" when modifying the files from Chimera. On one Mac, we updated to the latest version chimera. But when we run our extension, we get "Access Denied" error when try to remove some files. No such error occurs within the same Mac before updating the version. Do you have any clue why that happens.

If there is any question regarding our extension, please let me know! For more information about our lab, here is the link to our website: http://www.kiharalab.org/index.php.

Thank you in advance for your help and looking forward to your reply!

Best,

Yuhong Zha,

Kihara Bioinformatics Laboratory,

Department of Biological & Computer Science at Purdue University