Hi Eric, thank you for the answer. It means creating a registry check exception in Wise Care 365 could solve above mentioned problem ...? Milan ________________________________ Od: Eric Pettersen <pett@cgl.ucsf.edu> Odoslané: streda 9. decembra 2020 1:26 Komu: Nagy Milan <nagy@fpharm.uniba.sk> Kópia: chimera-users@cgl.ucsf.edu <chimera-users@cgl.ucsf.edu> Predmet: Re: [Chimera-users] Chimera and All-in-One system tune up tools Hi Milan, According to the Wise Care 365<https://www.wisecleaner.com/wise-care-365.html> web page, it will "stop any processes that try to secretly change Windows registry". Chimera adds keys to the registry. --Eric Eric Pettersen UCSF Computer Graphics Lab On Dec 7, 2020, at 11:31 PM, Nagy Milan <nagy@fpharm.uniba.sk<mailto:nagy@fpharm.uniba.sk>> wrote: Hello, how to solve following problem: after using all-in-one system tune up tools (Wise Care 365 Pro or Ashampoo Win Optimizer) Chimera stopped to work. Greetings Milan _______________________________________________ Chimera-users mailing list: Chimera-users@cgl.ucsf.edu<mailto:Chimera-users@cgl.ucsf.edu> Manage subscription: https://plato.cgl.ucsf.edu/mailman/listinfo/chimera-users