Dear Colleagues,

Thanks for developing such wonderful tools as Chimera for molecular dynamics analysis of structure.

Please I have two questions:

1. Is it possible to calculate Gibbs free energy  from complexes on UCSF Chimera,  for examples when  complexes are solvated?

2. On building structures , is it possible to simulate how a given complex could bind DNA oligos , for example  when one makes  changes in single nucleotides and ask  a given  DNA binding TF structure to bind it on Chimera?

I would look forward to your response to these questions. I would also be very happy if I could speak by phone with the administrators.

Thanks.

Best wishes,

Chidiebere U Awah MD Msc

PhD student , Molecular Medicine

Hannover Medical School , Germany.