Hi- I'm a huge fan of Chimera, and I frequently need to superimpose a dozen or more comparative models onto a template protein using MatchMaker. At present, one cannot even rotate the view until all matches have completed, which can take a few minutes on a single core. Based on old messages[1], it sounds like you might be "interested in allowing use of multiple cores for specific compute intensive tasks," and this seems to me like a good candidate. This use case involves many matches, which I think are completely independent of one another. Also, these models have identical length and sequence, so the runtimes should be fairly close to one another (although that wouldn't necessarily be true in the general case). I'm sure that adding multi-threading to a tool is not trivial, but it seems as though this feature might have a high "bang for the buck" on today's multicore machines. Thanks for considering it, -Jonathan 1. E.g. http://www.cgl.ucsf.edu/pipermail/chimera-users/2011-January/005901.html -- Jonathan Sheehan, Ph.D. Computational Structural Biology Vanderbilt Univ. Ctr. for Struct. Biol. 5137 MRB3, 465 21st Avenue S. Nashville, TN 37232-8755 615-936-2516