Hi Nihshanka, There is a parameter called "vertex density" that can be adjusted when computing a molecular surface in Chimera. Open a PDB model, use menu entry Actions / Surface / show, open Model Panel with menu entry Favorites / Model Panel, double click on the MSMS surface listed in Model Panel to get the surface attributes dialog. Then change the vertex density value (default 2) and press the Enter key to recalculate the surface. To see how many points you are getting change the "representation" setting in the attributes dialog to "mesh". I believe the vertex density means points per square angstrom. This method can reduce the number of surface points to a few per atom at the surface. If you want fewer points than that then other techniques would be needed involving writing Python code to sample the mesh of points more coarsely. Tom