Hi Smith, The latest ChimeraX daily builds (not the production release) include getting AlphaFold-predicted structures from the freely available AlphaFold Database. However, these are single-chain predictions only. There is an option to superimpose the single-chain predictions on an experimentally determined structure of a multimer so that the result looks like a multimer, but that is not truly the same as predicting the multimer. AlphaFold Database: <https://alphafold.ebi.ac.uk/> ChimeraX AlphaFold tool and command: <https://rbvi.ucsf.edu/chimerax/docs/user/tools/alphafold.html> <https://rbvi.ucsf.edu/chimerax/docs/user/commands/alphafold.html> I hope this helps, Elaine ----- Elaine C. Meng, Ph.D. UCSF Chimera(X) team Department of Pharmaceutical Chemistry University of California, San Francisco
On Aug 31, 2021, at 4:28 AM, tim smith via Chimera-users <chimera-users@cgl.ucsf.edu> wrote:
Hi All, Apologies for the nonrelated question!!
Wondering if there are any tools (can make in chimera/chimerax/Pymol) that predict or build protein oligomers based on alphfold structure. Please let me know. I will be grateful for your kind responses. Thank you
Best Smith