I think it is probably a bug in the archaic Tk window toolkit Chimera uses, resulting from some change in macOS Catalina. ChimeraX uses the Qt window toolkit and it shows double clicked files without starting extra copies of the program. Tom

On Aug 7, 2020, at 8:10 AM, Elaine Meng wrote:

Hi Oli, Unfortunately it is a bug in Catalina itself, as discussed in this previous post and links therein...

http://www.cgl.ucsf.edu/pipermail/chimera-users/2020-June/016910.html

The only suggestion is to use ChimeraX instead, if possible for your specific workflow. Best, Elaine ----- Elaine C. Meng, Ph.D. UCSF Chimera(X) team Department of Pharmaceutical Chemistry University of California, San Francisco

...

On Aug 7, 2020, at 6:54 AM, Oliver Clarke wrote:

Hi, After upgrading to Mac OS X Catalina, Chimera now launches a new instance of the application every time I open a new file. Previously, if I for example double-clicked an MRC or PDB file, it would open in the existing instance of Chimera; Now, it launches a new instance each time, which pretty quickly leads to me having 20+ copies of Chimera running simultaneously. Has anyone else encountered this and found a way to revert to the original behavior? Cheers Oli

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