Dear Elsa, Yes, there is an interface in Chimera to homology-modelling using the Modeller program. You have to get a license key for Modeller, but it is free for academic use. See the Chimera manual for more about this tool and the link to the Modeller website for obtaining the license key: <http://www.rbvi.ucsf.edu/chimera/docs/ContributedSoftware/multalignviewer/modeller.html> There is also a Chimera tutorial, "Comparative Modeling": <http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/tutorials/dor.html> Best, Elaine ---------- Elaine C. Meng, Ph.D. UCSF Computer Graphics Lab (Chimera team) and Babbitt Lab Department of Pharmaceutical Chemistry University of California, San Francisco On Sep 15, 2014, at 11:20 AM, Elsa Marquez <emarquez@ualberta.ca> wrote:

Hi there! I'd like to create a model of a protein that hasn't been crystallized yet, there are a few other highly homologous proteins that have been crystallized and are at PDB, so I was wondering if CHIMERA, or if you know about other software, can be used to model the unknown protein structure based on the known structure of homologous proteins. Thank you, I really appreciate your help! Elsa Marquez