Hi Beni, The gzip message is just misleading. It is not an error and is explained here https://plato.cgl.ucsf.edu/pipermail/chimera-users/2015-July/011199.html The real problem is almost surely that your graphics driver is broken since it gets to "Initializing graphics" and then dies. Updating the graphics driver was the right thing to try. One other remote possibility is that some Chimera preference setting is causing startup to fail -- like maybe you enabled multisampling in the past and the new graphics driver wipes out whenever you try to use it. The location of preferences is C:\Users\username\AppData\Roaming\.chimera\ (from documentation here https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/preferences.html <https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/preferences.html>). You might rename that .chimera folder so Chimera starts with factory default preferences and try to start. Tom

On Mar 7, 2021, at 1:18 PM, Beni Sued <benisued@gmail.com> wrote:

Hey there I've been using UCSF chimera for some time with no problems but it is having trouble starting up, this is the error message:

Cannot execute 'gzip': no automatic decompression of .Z files

initializing general preferences loading Tix initializing graphics Return code: -1073741819 Press return or enter to to exit

precisely like this gentleman: https://plato.cgl.ucsf.edu/pipermail/chimera-users/2019-April/015675.html <https://plato.cgl.ucsf.edu/pipermail/chimera-users/2019-April/015675.html> and this https://www.cgl.ucsf.edu/pipermail/chimera-users/2011-December/007021.html <https://www.cgl.ucsf.edu/pipermail/chimera-users/2011-December/007021.html>

my dxdiag info is attached, nothing wrong jumps to me.

What I've tried: - uninstalling and reinstalling Chimera - manually installing GZIP for windows ( https://sourceforge.net/projects/gzip-for-windows/ <https://sourceforge.net/projects/gzip-for-windows/> ) - updating drivers (graphics drivers and chipset drivers) - getting the alpha version of the program - going to and fro compute mode in the the graphical settings

I'm using Chimera 1.15 and this is my hardware chipset b550m ryzen 5600x RX 590

in trying to fix it I learned about ChimeraX, I'm learning to use it, but I would still like to keep chimera until i can properly stop and change my workflow

thanks so much, let me know if I missed any info <DxDiag.txt>_______________________________________________ Chimera-users mailing list: Chimera-users@cgl.ucsf.edu Manage subscription: https://plato.cgl.ucsf.edu/mailman/listinfo/chimera-users