Hi Cao, Chimera Gaussian filtering is done by the “vop gaussian” command described in the Chimera manual https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/midas/vop.html#gaussian <https://www.cgl.ucsf.edu/chimera/docs/UsersGuide/midas/vop.html#gaussian> It convolves a 3d Gaussian function with a map, a very standard operation that smooths data. It is implemented with a fast Fourier transform. Look up “gaussian convolution” online to find more details about the math, for example, https://en.wikipedia.org/wiki/Gaussian_blur Tom

On Dec 12, 2018, at 11:35 PM, CAO, Sheng <1155083065@link.cuhk.edu.hk> wrote:

Dear Sir/Madam,

I am a Ph.D student from The Chinese University of Hong Kong that have just begun to learn structural biology.

I found that the Gaussion filtering in Chimera has a much better result than other programs. And I an quite interested in it.

Could you please share the principle of the Gaussion filtering algorithm used in Chimera?

Thank you.

Best Regards, Cao Sheng

Postgraduate of The Chinese University of Hong Kong Major: Chemistry E-mail: 904323223@qq.com <mailto:904323223@qq.com> Address: G55, Science Centre South Block, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong P.R.China

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