Hi Hernando, Chimera does include many ways to evaluate protein-protein interfaces, but nothing like the "shape complementarity" calculation done by that Sc program, sorry. As you may already know, the things you could do in Chimera include: - calculating H-bonds and contacts - showing molecular surfaces of the contact regions and calculating the surface area <http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/midas/measure.html#buriedArea> - showing "interface surface" with Intersurf tool <http://www.rbvi.ucsf.edu/chimera/docs/ContributedSoftware/intersurf/intersurf.html> - coloring surfaces by hydrophobicity, electrostatic potential, and even concavity/convexity <http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/tutorials/surfprop.html> <http://www.rbvi.ucsf.edu/chimera/docs/UsersGuide/tutorials/attributes.html#part2> Best, Elaine ----- Elaine C. Meng, Ph.D. UCSF Computer Graphics Lab (Chimera team) and Babbitt Lab Department of Pharmaceutical Chemistry University of California, San Francisco On Aug 7, 2013, at 8:47 AM, Hernando J Sosa wrote:

Dear Chimera, Is there a way to evaluate protein-protein interfaces (e.g. using a program like CCP4 Sc) within chimera?. Thanks Hernando