Thank you for your reply.

I do have the libOSMesa.so exist in our /usr/lib64/ directory. But it seems not the one ChimeraX is trying to import.

The ldd result show as the following:

ldd ./libexec/UCSF-ChimeraX/lib/python3.8/site-packages/osmesa/libOSMesa.so.8.0.0

./libexec/UCSF-ChimeraX/lib/python3.8/site-packages/osmesa/libOSMesa.so.8.0.0: /lib64/libm.so.6: version `GLIBC_2.29' not found (required by ./libexec/UCSF-ChimeraX/lib/python3.8/site-packages/osmesa/libOSMesa.so.8.0.0)

linux-vdso.so.1 (0x00007ffe625ef000)

libz.so.1 => /lib64/libz.so.1 (0x00007fbcc8d47000)

libpthread.so.0 => /lib64/libpthread.so.0 (0x00007fbcc8b27000)

libdl.so.2 => /lib64/libdl.so.2 (0x00007fbcc8923000)

libLLVM-10.so.1 => not found

libstdc++.so.6 => /lib64/libstdc++.so.6 (0x00007fbcc858e000)

libm.so.6 => /lib64/libm.so.6 (0x00007fbcc820c000)

libc.so.6 => /lib64/libc.so.6 (0x00007fbcc7e4a000)

libgcc_s.so.1 => /lib64/libgcc_s.so.1 (0x00007fbcc7c32000)

/lib64/ld-linux-x86-64.so.2 (0x00007fbcc97eb000)

On our centos 8 VM, it shows as:

linux-vdso.so.1 =>  (0x00007ffebc3c3000)

libz.so.1 => /lib64/libz.so.1 (0x00007f2fcf0c3000)

libpthread.so.0 => /lib64/libpthread.so.0 (0x00007f2fceea6000)

libdl.so.2 => /lib64/libdl.so.2 (0x00007f2fceca2000)

libLLVM-3.9-mesa.so => /lib64/libLLVM-3.9-mesa.so (0x00007f2fccd71000)

libstdc++.so.6 => /lib64/libstdc++.so.6 (0x00007f2fcca68000)

libm.so.6 => /lib64/libm.so.6 (0x00007f2fcc766000)

libc.so.6 => /lib64/libc.so.6 (0x00007f2fcc3a3000)

libgcc_s.so.1 => /lib64/libgcc_s.so.1 (0x00007f2fcc18c000)

/lib64/ld-linux-x86-64.so.2 (0x000055f2cf96c000)

librt.so.1 => /lib64/../lib64/librt.so.1 (0x00007f2fcbf84000)

So I feel like the ChimeraX mesa is imported but not the system one. 

Best, 

Zhe