Hi Aneel, Are you using an Intel Mac? Unfortunately the machine learning PyTorch package that Boltz uses stopped supporting Intel Macs so it will only run on Apple Silicon Macs (ARM M1,M2,M3,M4,... processors). I'll add an error message to Mac ChimeraX to explain that Boltz cannot be installed on Intel Mac. Tom
On Nov 25, 2025, at 11:50 AM, Aggarwal, Aneel via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:
Hello,
I am a new user and trying to use boltz on my iMac (Tahoe OS) and get the error below. Any suggestions?
Thanks, Aneel
Successfully created Boltz Python virtual environment /Users/aneel/boltz22. Now installing Boltz and required packages from PyPi. This may take tens of of minutes since Boltz uses many other packages totaling about 1 Gbyte of disk space including torch, scipy, rdkit, llvmlite, sympy, pandas, numpy, wandb, numba... /Users/aneel/boltz22/bin/python -m pip install https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip Collecting https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip
Using cached https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip
Installing build dependencies: started
Installing build dependencies: finished with status 'done'
Getting requirements to build wheel: started
Getting requirements to build wheel: finished with status 'done'
Preparing metadata (pyproject.toml): started
Preparing metadata (pyproject.toml): finished with status 'done'
INFO: pip is looking at multiple versions of boltz to determine which version is compatible with other requirements. This could take a while.
ERROR: Could not find a version that satisfies the requirement torch==2.7.1 (from boltz) (from versions: 2.0.0, 2.0.1, 2.1.0, 2.1.1, 2.1.2, 2.2.0, 2.2.1, 2.2.2)
ERROR: No matching distribution found for torch==2.7.1
[notice] A new release of pip is available: 24.0 -> 25.3
[notice] To update, run: /Users/aneel/boltz22/bin/python -m pip install --upgrade pip
Boltz installation failed. See ChimeraX Log for details _______________________________________________ ChimeraX-users mailing list -- chimerax-users@cgl.ucsf.edu To unsubscribe send an email to chimerax-users-leave@cgl.ucsf.edu Archives: https://mail.cgl.ucsf.edu/mailman/archives/list/chimerax-users@cgl.ucsf.edu/