Hi, We're having problems getting ChimeraX to run on Windows 10 21H1. Each time we try running it, the cursor spins for a second or so and then nothing happens. I checked the Event Viewer and see every time we try running it an error event shows up in the Windows Application Error Event Log. Here's the output that shows up in the log for each of those versions: ---------------------------------------- Faulting application name: ChimeraX.exe, version: 1.2.5.0, time stamp: 0x60ab2a1d Faulting module name: Qt5WebEngineCore.dll, version: 5.15.2.0, time stamp: 0x5fad38ab Exception code: 0x80000003 Fault offset: 0x000000000014baff Faulting process id: 0x2b14 Faulting application start time: 0x01d795f43b7d3176 Faulting application path: C:\Program Files\ChimeraX 1.2.5\bin\ChimeraX.exe Faulting module path: C:\Program Files\ChimeraX 1.2.5\bin\lib\site-packages\PyQt5\Qt\bin\Qt5WebEngineCore.dll Report Id: db7d3af7-6986-47ed-ba27-3ce5e6bfcbae Faulting package full name: Faulting package-relative application ID: ---------------------------------------- Faulting application name: ChimeraX.exe, version: 1.1.0.0, time stamp: 0x5f5afaf7 Faulting module name: Qt5WebEngineCore.dll, version: 5.12.9.0, time stamp: 0x5ee3364a Exception code: 0x80000003 Fault offset: 0x0000000001989fb3 Faulting process id: 0x25d4 Faulting application start time: 0x01d795f5be3a354e Faulting application path: C:\Program Files\ChimeraX 1.1\bin\ChimeraX.exe Faulting module path: C:\Program Files\ChimeraX 1.1\bin\lib\site-packages\PyQt5\Qt\bin\Qt5WebEngineCore.dll Report Id: 5284e8f0-d191-4d3d-a49f-a93dc84117b0 Faulting package full name: Faulting package-relative application ID: ---------------------------------------- Faulting application name: ChimeraX.exe, version: 1.3.0.0, time stamp: 0x611f7fb2 Faulting module name: Qt5WebEngineCore.dll, version: 5.15.2.0, time stamp: 0x5fad38ab Exception code: 0x80000003 Fault offset: 0x000000000014baff Faulting process id: 0x2940 Faulting application start time: 0x01d795f6781afa93 Faulting application path: C:\Program Files\ChimeraX 1.3.dev202108200941\bin\ChimeraX.exe Faulting module path: C:\Program Files\ChimeraX 1.3.dev202108200941\bin\lib\site-packages\PyQt5\Qt\bin\Qt5WebEngineCore.dll Report Id: c07bfcd1-8b63-4e87-9217-a1a77cc449f8 Faulting package full name: Faulting package-relative application ID: ---------------------------------------- As you can see, this happens on both of the most recent production versions of ChimeraX (1.2.5 and 1.1.0.0) as well as on the latest daily build (1.3.dev202108200941) as of 8/20/2021. Please let me know if there's any more information you need from us. Thanks, Mason -- Mason Long Information Technology Consultant ITS Client Technology Natural Resources Building 211C Humboldt State University 1 Harpst St. Arcata, CA 95521 (707) 826-5636 (email only for now) Create a new request for help at http://www.humboldt.edu/ithelp