Maybe experts can give more detail, but as I understand it, using ChimeraX "boltz" installs boltz-1 locally on your own machine: <https://rbvi.ucsf.edu/chimerax/docs/user/tools/boltz.html> <https://rbvi.ucsf.edu/chimerax/docs/user/commands/boltz.html> <https://www.rbvi.ucsf.edu/chimerax/data/boltz-apr2025/boltz_help.html> However, running boltz-1 will use Colabfold server for generating the deep multiple sequence alignment, and we do not have control over how/whether data is stored by that server. Other than that, I don't see anything in the help about data going in/out from your own computer. I hope this helps, Elaine ----- Elaine C. Meng, Ph.D. UCSF Chimera(X) team Resource for Biocomputing, Visualization, and Informatics Department of Pharmaceutical Chemistry University of California, San Francisco
On Jul 1, 2025, at 8:38 PM, Dario Passos via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:
Dear ChimeraX team,
I have a question regarding data privacy when using the Boltz-1 structure prediction tool within ChimeraX. Is the input or output data temporarily or permanently stored, logged, or shared in any way by UCSF, ColabFold, or any third-party services? Is there an option to ensure that all data remains strictly local and is not stored externally?
Thank you, Dario