Right now in ChimeraX, to avoid the network template lookup for ligands, you have two solutions: (1)  use UNL for the component name for ligands with unknown connectivity, or (2) in a mmCIF file, give the connectivity with the chem_comp and chem_comp_bond tables.   UNL comes from https://www.rcsb.org/ligand/UNL.

I agree that It is reasonable to have more component names avoid the network lookup.  I will ask the PDB what they suggest to avoid problems in the future.  But I will go ahead and add anything that starts with UNL optionally followed by an underscore or a digit.  That will be in tomorrow's daily build.

    -- Greg

Dear All,

I am often opening AlphaFold 3 co-folding structures including small molecules in ChimeraX. In these models, ligands were provided as SMILES and are called LIG_X (with X being the chain label) in the AF3 output model.cif file. Opening these structures is very slow on my machine, because ChimeraX searches for a template for the ligands and finally fails with the warning "Unable to fetch template for 'LIG_X': will connect using distance criteria".

Is there any workaround? E.g. by telling ChimeraX not to look for a template?

Thank you for your help,

Ute

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