Hi Saverio,

Perhaps it would not be as convenient as having ChimeraX as an interface to Boltz-1, but Boltz-2 is easy to install on a local machine. The outputs can then be used in ChimeraX and/or other molecular modeling and viewing platforms. My own installations of Boltz-2 and other AF3 replica codes are in conda environments on a Linux machine with a fairly fast CPU and GPUs.

Best wishes,

Rudy

Rudy J. Richardson, ScD, DABT
Molecular Simulations Laboratory
Room M6065 SPH-II 2029
University of Michigan
1415 Washington Heights
Ann Arbor, MI 48109-2029 USA

Tel: +1-734-936-0769
Fax: +1-734-763-8095

On Mon, Jun 30, 2025 at 11:51 AM saverio via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:
Hi Elaine,
thanks.
The use of Boltz 2 will be available in a next release of ChimeraX
or , if possible , as some sort of patch or using a local 
installation of Boltz 2?

Saverio

Il 30.06.2025 17:13 Elaine Meng ha scritto:

Hi Saverio,
Our expert on this topic is away for a few days, but my understanding is: currently no, you cannot use Boltz 2 with ChimeraX yet.  He has been working on it and hopes to have it available in the future, however.
Elaine
-----
Elaine C. Meng, Ph.D.                       
UCSF Chimera(X) team
Resource for Biocomputing, Visualization, and Informatics
Department of Pharmaceutical Chemistry
University of California, San Francisco
On Jun 30, 2025, at 2:49 AM, saverio via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote: Hi, it is possible to install the latest version ( 2.1.1 ) of boltz in ChimeraX 1.10 with the command boltz install? Thanks. Saverio

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