Hi Aneel, DId you try what it told you to do in the error message? ... namely:
[notice] A new release of pip is available: 24.0 -> 25.3
[notice] To update, run: /Users/aneel/boltz22/bin/python -m pip install --upgrade pip
I hope this helps, Elaine ----- Elaine C. Meng, Ph.D. UCSF Chimera(X) team Resource for Biocomputing, Visualization, and Informatics Department of Pharmaceutical Chemistry University of California, San Francisco
On Nov 25, 2025, at 11:50 AM, Aggarwal, Aneel via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:
Hello,
I am a new user and trying to use boltz on my iMac (Tahoe OS) and get the error below. Any suggestions?
Thanks, Aneel
Successfully created Boltz Python virtual environment /Users/aneel/boltz22. Now installing Boltz and required packages from PyPi. This may take tens of of minutes since Boltz uses many other packages totaling about 1 Gbyte of disk space including torch, scipy, rdkit, llvmlite, sympy, pandas, numpy, wandb, numba... /Users/aneel/boltz22/bin/python -m pip install https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip Collecting https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip
Using cached https://github.com/RBVI/boltz/archive/chimerax_boltz22.zip
Installing build dependencies: started
Installing build dependencies: finished with status 'done'
Getting requirements to build wheel: started
Getting requirements to build wheel: finished with status 'done'
Preparing metadata (pyproject.toml): started
Preparing metadata (pyproject.toml): finished with status 'done'
INFO: pip is looking at multiple versions of boltz to determine which version is compatible with other requirements. This could take a while.
ERROR: Could not find a version that satisfies the requirement torch==2.7.1 (from boltz) (from versions: 2.0.0, 2.0.1, 2.1.0, 2.1.1, 2.1.2, 2.2.0, 2.2.1, 2.2.2)
ERROR: No matching distribution found for torch==2.7.1
[notice] A new release of pip is available: 24.0 -> 25.3
[notice] To update, run: /Users/aneel/boltz22/bin/python -m pip install --upgrade pip
Boltz installation failed. See ChimeraX Log for details _______________________________________________ ChimeraX-users mailing list -- chimerax-users@cgl.ucsf.edu To unsubscribe send an email to chimerax-users-leave@cgl.ucsf.edu Archives: https://mail.cgl.ucsf.edu/mailman/archives/list/chimerax-users@cgl.ucsf.edu/