tips for large 180kda protein for morph

I morphed a 180kda protein. Trying to view it in stereo with surface. Works good but slow. Any tips/ideas to make the morph faster? Krishnan Raman Executive Director, Structural Biology BioCryst Pharmaceuticals CONFIDENTIALITY NOTICE This email, including any attachments, may contain confidential or legally privileged information that is intended only for the individual or entity to whom it is addressed. If you are not the intended recipient, please be advised that any dissemination, distribution or copying of this email and any attachment is strictly prohibited. If you have received this email in error, please reply to the sender so that BioCryst Pharmaceuticals, Inc. can take corrective measures and then permanently delete this email and any attachment, including any printed copies. Thank you.

It's really difficult to say without knowing more about your setup. Some possibilities include: (A) not showing the side view, (B) running locally on your computer instead of remotely, (C) getting a graphics card with more memory, (D) getting a faster graphics card, (E) getting more main memory and/or faster memory, (F) getting a faster CPU, (G) use a desktop/workstation computer instead of a laptop (with suitable graphics and memory), .... So most guesses include improving your computer :-). Without knowing your setup, it is very difficult to guess where the bottleneck probably is. -- Greg On 9/20/2022 12:58 PM, Krishnan Raman via ChimeraX-users wrote:
I morphed a 180kda protein. Trying to view it in stereo with surface. Works good but slow.
Any tips/ideas to make the morph faster?
Krishnan Raman
/Executive Director, Structural Biology/
/BioCryst Pharmaceuticals/
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Hi Krishnan, The probable reason for it being slow to play through a morph with a surface is because ChimeraX will recompute the surface at each time step and that can take seconds. The way to avoid that is to have the morph as say 50 separate models that you play through with the mseries command where the surfaces have all been computed in advance. The mseries command will just hide and show models which is fast. If instead you have one morph model with 50 coordinate sets then the surface cannot be precomputed. To turn your morph into separate models save it to PDB or mmcif file ("save morph.pdb model #3 allCoords true"), then open that file as multiple models ("open morph.pdb coordsets false"). Tom
On Sep 20, 2022, at 12:58 PM, Krishnan Raman via ChimeraX-users <chimerax-users@cgl.ucsf.edu> wrote:
I morphed a 180kda protein. Trying to view it in stereo with surface. Works good but slow. Any tips/ideas to make the morph faster?
Krishnan Raman Executive Director, Structural Biology BioCryst Pharmaceuticals
CONFIDENTIALITY NOTICE
This email, including any attachments, may contain confidential or legally privileged information that is intended only for the individual or entity to whom it is addressed. If you are not the intended recipient, please be advised that any dissemination, distribution or copying of this email and any attachment is strictly prohibited. If you have received this email in error, please reply to the sender so that BioCryst Pharmaceuticals, Inc. can take corrective measures and then permanently delete this email and any attachment, including any printed copies. Thank you.
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participants (3)
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Greg Couch
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Krishnan Raman
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Tom Goddard