Please join us for the Novartis Symposium on Novel Approaches to Therapeutics and Targets. Speakers include Eric Martin and Cindy Shafer of Novartis and Kate Carroll from the Scripps Research Institute. See the attached flyer for more details.

Thursday, January 30th
9:00 am - 2:00 pm
Smith Cardiovascular Research Building
Room 159

**Please note, Kate Carroll’s BBC Seminar Series talk will be from 1-2pm in CVRI Rm 159 and NOT in Byers Auditorium at 12pm.

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About the invited speakers:
Eric Martin is Director of Computational Chemistry at Novartis. He is credited with having started the field of combinatorial library design in the early 90s. Over the past 25 years he has worked in computational chemistry, analytical instrument development, environmental-fate modeling, drug design and herbicide design. His recent research includes the development of three novel kinase virtual screening methods, which he has combined with experimental IC50 and structural data to screen 4 million compounds across the entire kinome achieving unprecedented speed and accuracy.

Cindy Shafer is a Project Leader in the Global Discovery Chemistry Group at Novartis. While at Novartis, she has worked on oncology, diabetes and anti-viral programs from the hit-to-lead stage through lead optimization. Several of these programs have progressed to the clinic including TKI258/dovitinib (Ph III), HSP990 and the mutant-b-Raf inhibitors RAF265 and LGX818 (Ph III). In addition, she has led several early stage programs to develop tool compounds to further elucidate the biological relevance in oncology settings.

Kate Carroll is an Associate Professor of Chemistry at The Scripps Research Institute, Florida Campus. Her research focuses on the role of oxidative thiol modifications in the dynamic regulation of signaling pathways and physiological processes. Her work includes the development of chemical probes and proteomic technologies for the dissection of redox signaling pathways. Recently she has applied these tools to the global analysis of sulfenic acid modified proteins for the identification of signaling networks regulated by cysteine oxidation.
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We thank Novartis, CVRI and UCSF BBC Graduate Groups for their participation and generous financial support.

Julia Molla
UC San Francisco
Program Coordinator, Biological& Medical Informatics and Chemistry&
Chemical Biology
600-16th St. MC2280
San Francisco, CA 94158-2517
415-476-1914 phone

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