-- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Department of Pharmaceutical Chemistry University of California at San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary@salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali@salilab.org; Web http://salilab.org Begin forwarded message:
From: "Stephens, Susan [JRDUS]" <sstephens1@ITS.JNJ.COM> Subject: Intern Positions at Janssen Pharmaceutical R&D Date: April 25, 2012 5:14:59 PM PDT To: "Stephens, Susan [JRDUS]" <sstephens1@ITS.JNJ.COM>
The In Silico Immunology team in Janssen Pharmaceutical Research & Development L.L.C., a member of Johnson and Johnson's family of companies, is recruiting for two Research Scientists for 2012 Pharmaceutical R&D internships, located in Radnor, PA.
Please share information about the positions with any candidates that may be interested. Formal applications should be made on the J&J Career Web site (http://careers.jnj.com).
Kind regards,
Susie
2012 PHARMACEUTICAL R&D INTERNSHIPS in In Silico Immunology - 000004FN
1. Network Pharmacology
Janssen Pharmaceutical Research & Development is seeking a graduate student with strong computational skills interested in an internship position in the Network Pharmacology group. The candidate’s current research area should be Systems Biology, Bioinformatics, Computer Science or Engineering, have a solid understanding of network analysis methods and biology as well as programming experience and ability to write R, Matlab and/or Perl script. Experience with large-scale genomics data and a solid understanding of bioinformatics tools and databases is a plus. The successful candidate will focus on the development of bioinformatics approaches to integrate and analyze data from various cutting-edge projects in the Immunology Therapeutic Area.
The candidate will develop and investigate methods to understand dysregulated mechanisms in disease using Network Pharmacology approaches. They will conduct network analysis and inference on large-scale data that provides a global view of the disease that would help determining its representation in the relevant in-vivo and in-vitro models.
· Construct biological networks from molecular profiling data and from molecular interaction data stored in databases
· Conduct research on topological analysis to find key regulatory genes/proteins via biological network and genomic data
· Identify robust sub-networks using different data modalities (mRNA, proteins, DNA, etc.)
· Reconstruct network modules from the identified key regulators to discover affected biological processes and disease-related genes
2. Lifecycle Management
Janssen Pharmaceutical Research & Development is seeking a graduate student with strong computational skills interested in an internship position in focused on Lifecycle Management. The candidate’s current research area should be Systems Biology, Bioinformatics, Computer Science or Engineering. The intern will be responsible for developing algorithms and workflows that will facilitate the analysis of preclinical and clinical data. Through the implementation of these workflows, the intern will explore potential new disease indications for marketed and late stage development clinical compounds across the large and small molecule Immunology Therapeutic Area portfolio. The successful intern will work with the In Silico Immunology team to develop computational methodologies that will enable the combination of data outputs from different software platforms to build in silico networks of autoimmune and pulmonary diseases.
Experience in computational algorithms and mathematical modeling, preferably of biological or disease networks, is required for this position. Analysis of large datasets, especially microarray data, is preferred. Expertise in computer software such as R, Matlab, Ingenuity Pathways, and Cytoscape is also desirable.