FYI ---------- Forwarded message --------- From: Robert Batey <rob.batey@utoronto.ca> Date: Thu, Apr 28, 2022 at 8:08 AM Subject: Re: question - re: co-crystal structure ligand based design To: Brian Shoichet <bshoichet@gmail.com> Dear Brian Hope that you are well. I don’t know whether you saw this, but we have a full-time tenure stream position in the area of computational chemistry applied to medicinal chemistry and chemical biology. The appointment is at the rank of Associate Professor or Professor with an expected start date of July 1, 2023. The posting for this position can be found here: https://jobs.utoronto.ca/job/Toronto-Associate-ProfessorProfessor-Computatio.... All application materials, including reference letters, must be received by *May 17, 2022.* Successful candidates may also be nominated for a *Canada Excellence Research Chair <https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cerc.gc.ca%2Fprogram-programme%2Fcpan-pccs-eng.aspx&data=04%7C01%7Crob.batey%40utoronto.ca%7C50fbece85fb54631f40b08da1cb84a02%7C78aac2262f034b4d9037b46d56c55210%7C0%7C0%7C637853875073643268%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=jCdAlIlgzjkxBES6rW0y%2FFESz6DCEFuKUhqd1ezB7aE%3D&reserved=0>* in Medicinal Chemistry, AI/Machine Learning and Computational Chemistry, Chemical Biology valued at $1 million/year for 8 years. The Canada Excellence Research Chairs (CERC) program is intended to support world‑renowned researchers and their teams in establishing ambitious research programs at Canadian universities. Nominees to the CERC opportunity will be internationally leading researchers whose proposed research program aligns with one or more of the *Government of Canada’s Science, Technology and Innovation priority areas <https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cerc.gc.ca%2Fprogram-programme%2Fcpan-pccs-eng.aspx&data=04%7C01%7Crob.batey%40utoronto.ca%7C50fbece85fb54631f40b08da1cb84a02%7C78aac2262f034b4d9037b46d56c55210%7C0%7C0%7C637853875073643268%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=jCdAlIlgzjkxBES6rW0y%2FFESz6DCEFuKUhqd1ezB7aE%3D&reserved=0>*. The labs would be primarily located in the Princess Margaret Cancer Centre. I wonder whether you know anyone who you think might be appropriate? Would you share this opening with your networks? Let me know if you have any questions. Cheers Rob *From: *Undisclosed Recipients <rob.batey@utoronto.ca> *Date: *Wednesday, March 16, 2022 at 1:50 PM *To: *Brian Shoichet <bshoichet@gmail.com> *Cc: *Daniel Erlanson <erlanson@gmail.com> *Subject: *Re: question - re: co-crystal structure ligand based design Dear Brian and Dan (nice to be virtually acquainted btw, I enjoy the blog) Thanks for this – very helpful, and two interesting examples. In the case we have the two orientations are linked by a single bond rotation, and it enabled us to design an entirely new class of compound that allowed for both of the two orientations to be mimicked in a single compound. Cheers Rob –––––––––––––– Robert A. Batey, Ph. D. Professor and Chair Department of Chemistry <https://www.chemistry.utoronto.ca/>, LM 151 University of Toronto <https://www.utoronto.ca/> 80 St. George St., Toronto, ON CANADA, M5S 3H6 Chair's office: 416-978-3566; fax: 416-978-1631 Web: http://www.chem.utoronto.ca/staff/RAB/index.html Linked-In: https://www.linkedin.com/in/robert-batey-156221a2 I wish to acknowledge this land on which the University of Toronto operates <https://indigenous.utoronto.ca/about/land-acknowledgement/>. For thousands of years it has been the traditional land of the Huron-Wendat, the Seneca, and the Mississaugas of the Credit. Today, this meeting place is still the home to many Indigenous people from across Turtle Island and we are grateful to have the opportunity to work on this land. –––––––––––––– *From: *Brian Shoichet <bshoichet@gmail.com> *Date: *Saturday, February 5, 2022 at 8:47 PM *To: *Undisclosed Recipients <rob.batey@utoronto.ca> *Cc: *Daniel Erlanson <erlanson@gmail.com> *Subject: *Fwd: question - re: co-crystal structure ligand based design You don't often get email from bshoichet@gmail.com. Learn why this is important <http://aka.ms/LearnAboutSenderIdentification> Dear Rob, I rec'd these references from Dan Erlanson, copied. They speak to your case, I think you'll find them useful in framing your cool story. Brian ---------- Forwarded message --------- From: *Daniel Erlanson* <erlanson@gmail.com> Date: Sat, Feb 5, 2022 at 7:59 AM Subject: Re: question - re: co-crystal structure ligand based design To: Brian Shoichet <bshoichet@gmail.com> Hi Brian, Nice to hear from you! A couple examples come to mind, though I feel like there are more: https://practicalfragments.blogspot.com/2020/05/merging-two-of-same-fragment... <https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpracticalf...> https://practicalfragments.blogspot.com/2013/10/fragment-merging-revisited-c... <https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpracticalf...> BTW I liked your recent SARS-CoV-2 aggregation paper - unfortunately too much crap got published in the past couple years. Cheers, Dan -- Brian Shoichet, Professor, UCSF latest science from the lab: *https://bkslab.org/ <https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbkslab.org%2F&data=04%7C01%7Crob.batey%40utoronto.ca%7C1ad8216721ae437abd4608d9e912723b%7C78aac2262f034b4d9037b46d56c55210%7C0%7C0%7C637797088685771133%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=l4H5pnLpPzTMEXodBu0f1GWiXDntyK5STRUOJN1PbKE%3D&reserved=0>* -- Brian Shoichet, Professor, UCSF latest science from the lab: *https://bkslab.org/ <https://bkslab.org/>*