---------- Forwarded message --------- From: Colin Smith <colin.smith@wesleyan.edu> Date: Thu, Dec 9, 2021 at 12:50 PM Subject: Open Postdoc Positon To: Colin Smith <colin.smith@wesleyan.edu> Dear Colleagues, I have a postdoc position currently open in my group to develop and apply computational techniques for refining NMR structures. I would appreciate it if you would distribute the description below to your lab members or colleagues that may know suitable candidates. Thanks and happy holidays! Colin Colin A. Smith Assistant Professor Department of Chemistry Wesleyan University +1 860 685-3274 http://smithlab.wesleyan.edu The Smith Lab at Wesleyan University has an immediate opening for a postdoc (http://smithlab.research.wesleyan.edu/joining). Our lab specializes in developing and applying methods for computationally modeling NMR data. We use these and other techniques to study dynamics of computationally designed proteins and allostery in natural proteins. We have recently developed the Kinetic Ensemble theoretical framework that allows us to rigorously model how many types of motion affect the Nuclear Overhauser Effect (NOE), which is foundational to NMR-based structure determination. We have shown that approximations made in traditional NOE-based structure determination can result in significant underfitting of the data. We would like to now extend this methodology to enable direct refinement of highly accurate protein ensembles using leading biomolecular modeling software packages. We are seeking an individual with programming experience in a compiled language like C++ who will create and apply next-generation NOE restraints using the Kinetic Ensemble methodology. Together with advanced NOE peak integration using our FitNMR software package, the overall goal is to develop a fully quantitative pipeline to generate the most accurate solution ensembles of proteins to date. We hope this will advance the field of NMR structure determination and yield insights into how the solution state dynamics of proteins at the atomic level differ from those found in crystals. Suitable candidates are encouraged to contact Prof. Colin Smith ( colin.smith@wesleyan.edu) to apply and/or discuss this opportunity. Individuals having demonstrated experience with high-performance programming in the context of a large existing codebase are especially well-suited for this position. -- Michael J Keiser, PhD Associate Professor, UCSF p/1-415-886-7651 calendly.com/mjke