UCSF ChimeraX version 1.12 has been released! ChimeraX includes user documentation and is free for noncommercial use. Download for Windows, Linux, and MacOS from: https://www.rbvi.ucsf.edu/chimerax/download.html Updates since version 1.11 (December 2025) include: - OpenFold3 structure prediction - Boltz server capabilities - cartoons with straight cylinder helices (alternative to curved tube helices) - 3D-SNFG glycan representations - Match->Align to create a multiple sequence alignment from a 3D superposition - label residues with color-coded grids of amino acid prevalences from an associated multiple sequence alignment in Profile Grid - Find Cavities options to include cofactors, restrict search to box - trajectory clustering - commands to reproduce clipping plane positions - Mutation Scores tool for analysis of deep mutational scanning results For details, please see the ChimeraX change log: https://www.rbvi.ucsf.edu/trac/ChimeraX/wiki/ChangeLog On behalf of the team, Elaine ----- Elaine C. Meng, Ph.D. UCSF Chimera(X) team Resource for Biocomputing, Visualization, and Informatics Department of Pharmaceutical Chemistry University of California, San Francisco