[chimerax-users] Re: ChimeraX & ConSurf

Hi Martin, I don't think including ConSurf directly in ChimeraX is feasible. The source code seems to be oriented for server use and likely only compiles on Linux. It also requires multiple additional packages (including Perl) with various licenses and compilation needs of their own. It also requires the installation of the SwissProt and TrEMBL databases. The latter is 58GB compressed. So I think I'm going to hold out for the ConSurf website to come back online. :-) Unfortunately the message the site gives today says it has been down since mid-September due to "serious security problems", but that nonetheless they are working on getting it back online. --Eric Eric Pettersen UCSF Computer Graphics Lab

On Dec 4, 2023, at 7:04 AM, martin.brehm--- via ChimeraX-users wrote:

Dear ChimeraX developers,

I have a question regarding a potential upgrade of ChimeraX. Would it be possible to include the functionality of ConSurf, a tool to plot the degree of sequence conservation onto a model, into ChimeraX? The code for this is publically available on GitHub: https://github.com/Rostlab/ConSurf https://github.com/Rostlab/ConSurf See this publication for more information: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987940/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987940/ Thanks a lot in advance and have a nice day!

Best regards Martin Brehm

Martin Brehm – PhD Student Falk Lab – Max Perutz Labs Vienna Room 1.624 – Phone +43 14277 74361 martin.brehm@univie.ac.at mailto:martin.brehm@univie.ac.at

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