October 2011 - compbio-allhands@cgl.ucsf.edu

[Compbio-allhands] 11/3/11 Seminar with Adam Cohen
by Nicole Takesono Flowers 31 Oct '11

31 Oct '11

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Sytems Thursdays, 12 Noon Genentech Hall Auditorium Simulcast to Parnassus Campus S-161 Adam Cohen Harvard University Fluorescent voltage-indicating proteins: imaging spiking from E. coli to neurons November 3, 2011 B. Huang, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology. Nicole Takesono Flowers CCB Graduate Program Assistant AMBER Software Administrator UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94158-2517 Phone: (415) 502-6518 Fax: (415) 514-1546

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[Compbio-allhands] Fwd: Faculty Position in Chemical Biology at UNC
by Brian Shoichet 31 Oct '11

31 Oct '11

Fyi Brian Shoichet Professor Dept. of Pharmaceutical Chemistry UCSF http://shoichetlab.compbio.ucsf.edu ---------- Forwarded message ---------- From: "Weeks, Kevin" <weeks(a)unc.edu> Date: Oct 31, 2011 4:01 AM Subject: Faculty Position in Chemical Biology at UNC To: Dear Colleagues, The Carolina Center for Genome Sciences is partnering with the Department of Chemistry to conduct a junior faculty search with a research focus in Chemical Biology and Chemical Genomics. This new colleague will join a group of highly inventive laboratories spanning the Departments of Biology, Chemistry and Computational Biology in the new Genome Sciences Building at UNC. The formal advertisement is attached. We ask you to encourage exceptional candidates to apply. With best regards, Kevin -- Kevin M Weeks . Kenan Distinguished Professor Department of Chemistry . Kenan Labs . 125 South Road University of North Carolina . Chapel Hill NC 27599-3290 http://www.chem.unc.edu/rna

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[Compbio-allhands] 10/27/11 Seminar with Jim Ferrell
by Nicole Takesono Flowers 26 Oct '11

26 Oct '11

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Sytems Thursdays, 12 Noon Genentech Hall Auditorium Simulcast to Parnassus Campus S-161 Jim Ferrell Stanford University Dissecting the Mitotic Trigger October 27, 2011 W. Lim, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology. Nicole Takesono Flowers CCB Graduate Program Assistant AMBER Software Administrator UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94158-2517 Phone: (415) 502-6518 Fax: (415) 514-1546

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[Compbio-allhands] Fwd: Biochemistry Assistant Professor Position at Utah State University
by Brian Shoichet 24 Oct '11

24 Oct '11

Brian Shoichet Professor Dept. of Pharmaceutical Chemistry UCSF http://shoichetlab.compbio.ucsf.edu ---------- Forwarded message ---------- From: "Geraldine Child" <geri.child(a)usu.edu> Date: Oct 24, 2011 9:15 AM Subject: Biochemistry Assistant Professor Position at Utah State University To: Dear Colleagues, I would like to bring to your attention our current search for an assistant professor in the area of Biochemistry. Details of the position and application process are given below. Please pass this information on to appropriate postdoctoral associates in your laboratory. We are especially interested in receiving applications from female and minority candidates. Thank you, Alvan C. Hengge Department Head, Professor Department of Chemistry and Biochemistry Utah State University Logan UT 84322-0300 ____________________________________________________________________________________ Assistant Professor Biochemistry Utah State University The Department of Chemistry and Biochemistry at Utah State University invites applications for a R. Gaurth Hansen tenure-track assistant professor position in Biochemistry to begin Fall 2012. The successful candidate will develop a research program that complements at least one departmental focus area, such as macromolecular structure and function, or catalysis and reaction mechanism. Applicants must have a PhD in biochemistry, chemistry, or a related field, and postdoctoral experience. The position requires the development of an externally-funded research program, as well as teaching at the undergraduate and graduate levels. Candidates capable of teaching biophysical chemistry are particularly encouraged to apply. Applicants should submit a curriculum vitae, a concise description of future research projects, a description of how the research to be pursued complements existing research focus areas in the Department, a description of teaching experience and preferred teaching area(s), and the names and email addresses of three references. Apply online at http://jobs.usu.edu (REQ ID 052891). Evaluation of applicants will begin November 1, 2011 and will continue until the position is filled. Utah State University, located in Logan, Utah, is an Equal Opportunity/Affirmative Action Employer committed to assembling a diverse faculty. Women and members of minority groups are strongly encouraged to apply.

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[Compbio-allhands] Fwd: Opportunity for young investigators in Sweden
by Andrej Sali 24 Oct '11

24 Oct '11

Begin forwarded message: > From: Arne Elofsson <arne(a)bioinfo.se> > Subject: Opportunity for young investigators in Sweden > Date: October 24, 2011 5:41:31 AM PDT > To: Christine Orengo <orengo(a)biochem.ucl.ac.uk>, David Baker <dabaker(a)u.washington.edu>, Andrej Sali <sali(a)salilab.org>, d.jones(a)cs.ucl.ac.uk, e.bornberg(a)uni-muenster.de, Frishman Dmitrij <d.frishman(a)wzw.tum.de>, "David A. Liberles" <liberles(a)uwyo.edu> > > > Dear Colleagues > > At the moment there are openings for excellent young scientists in Sweden through a very well funded program named Wallenber Academy Fellows, see below for a link to a Swedish announcement. Therefore if you have any very good candidates with a PhD awarded between 2004 and 2007 and that have a serious interest to move to Sweden and work in an area related to ours, I would very much appreciate if you forwarded this mail to them. > > The application procedure is two steps. First the department can nominate candidates to the head of the university with a deadline of Dec 3 and then the university will select up to 10 candidates (of which 40% needs to be external). These will then have until Feb 29 to write the application. The grant is for 5 years and between 1 and and 1.5 MSEK (110-165 kEuro) per year and in addition the university will guarantee 50% of the salary and provide some sort of tenure track. > > > Here is the link (in Swedish) > > http://www.wallenberg.com/docs/kaw/nomineringsinbjudan-wallenberg-academy-f… > > Yours > > Arne > > --------------------------------------------------------- > Prof. Arne Elofsson Dep of Biochemistry and Biophysics > Tel:+46-8-16 4672 Stockholm University > Fax:+46-8-15 3679 10691 Stockholm, Sweden > Mobile: +46 70 695 1045 > Directions: see http://bioinfo.se/misc/directions.html > Net: arne(a)bioinfo.se http://bioinfo.se/ > -- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Director, California Institute for Quantitative Biosciences at UCSF Department of Pharmaceutical Chemistry University of California at San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org

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[Compbio-allhands] Comp Bio/Drug Discovery Internship opportunity at Novartis Emeryville
by Schnoes, Alexandra 21 Oct '11

21 Oct '11

Hello, This was circulated a bit ago but they are still looking. If you are interested please contact Eric Martin (below). I get the feeling they would love to take someone from UCSF. I know a little bit about the position, so if you have some basic questions you can shoot them to me too. Job description for Student Internship in Compuational Drug Discovery Most drug leads are discovered through experimental high-throughput screens, which cost about $1,000,000 and take 6-9 months. Efforts over many years to develop computational “in silico” screens have not resulted in sufficiently accurate models to provide a practical alternative. Recently, at Novartis, a protein family-based approach has produced models approximating experimental accuracy for the special cases of kinase and serine/cisteine protease enzyme families. These families include many pharmaceutically important drug targets. This 1-year internship involves learning to train and employ these models on new and existing drug discovery targets. The ideal candidate would understand the physical properties of organic compounds and proteins, and how they can interact, as well as familiarity with computer programming and running scientific calculations. Eric Martin ( eric.martin(a)novartis.com<mailto:eric.martin@novartis.com> ) Director, Computational Chemistry Novartis 4560 Horton St. Emeryville, CA 94608 510-923-3306 -- Alexandra Schnoes, PhD Program Coordinator, Graduate Student Internships for Career Exploration Scientist, Babbitt Laboratory University of California San Francisco 513 Parnassus Ave, S-224 Campus Box 0410 San Francisco, CA 94143 Tel: 415-476-0572 Fax: 415-476-0689 Email: alexandra.schnoes(a)ucsf.edu<mailto:alexandra.schnoes@ucsf.edu> Web: http://gsice.ucsf.edu<http://gsice.ucsf.edu/>

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[Compbio-allhands] Friday Seminar: The Role of Conformational Dynamics of G-Protein Coupled Receptors in Drug Design
by JoAnne Williams 19 Oct '11

19 Oct '11

This seminar may be of interest to you: -------------------------------------------- *Date: Friday, October 21, 2011* *Time: 11:00a-12:00p* *Location: BH215* *Speaker: **Prof. Nagarajan Vaidehi* *Department of Immunology, Beckman Research Institute, City of Hope Cancer* *Research Center* *The Role of Conformational Dynamics of G-Protein Coupled* *Receptors in Drug Design* Abstract: The superfamily of membrane proteins known as G-protein coupled receptors (GPCRs), mediate signal transduction in a wide array of different cell types. Drugs targeting GPCRs represent the core of modern medicine. Upon stimulation by a variety of signaling molecules (ranging from light to small molecules and large proteins), GPCRs trigger a diverse set of signaling pathways in the cell, by coupling to different intracellular proteins to transduce the signal. This functional diversity in signaling is achieved by the structural conformational dynamics of these receptors. In this talk, I will demonstrate that the combination of computational methods, X-ray crystallography, and fluorescence spectroscopy provides insight into the conformational ensemble sampled by GPCRs. Additionally, the effect of how the ligand binding leads to a shift in the relative population density in this ensemble will be discussed. An example of how structural insights gained from these fundamental biophysical techniques can be used to design drugs targeting a specific signaling pathway that is relevant in pancreatic cancer will be outlined. -- JoAnne Williams, Admin Analyst Shoichet & Jacobson Labs Department of Pharmaceutical Chemistry University of California, San Francisco UCSF MC 2550 Byers Hall, Rm 508 1700 4th Street San Francisco, CA 94158-2517 tel: (415) 514-4261 or (415) 502-7050 email: *joanne(a)picasso.ucsf.ed <http://joanne@picasso.ucsf.edu/>u* * * * *

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[Compbio-allhands] Fwd: International PhD Program - Announcement Spring Selection 2012
by Andrej Sali 19 Oct '11

19 Oct '11

Begin forwarded message: > From: "Wolf, Ingrid" <inwolf(a)biochem.mpg.de> > Subject: International PhD Program - Announcement Spring Selection 2012 > Date: October 19, 2011 7:32:25 AM PDT > To: "'Sali'" <sali(a)salilab.org> > > Dear Prof. Sali, > > Please find enclosed the announcement of our international PhD program in molecular and cellular life sciences. > > The International Max Planck Research School for Molecular and Cellular Life Sciences is jointly conducted by the Max Planck Institutes of Biochemistry, Neurobiology and Psychiatry, the Ludwig Maximilian University Munich and the Technical University Munich. The program, covering the disciplines of biochemistry, cell biology, molecular medicine, neurobiology and structural biology, offers a research oriented comprehensive and interdisciplinary training to doctoral students from all over the world. More than 60 distinct research projects are currently available. > > Qualified candidates are now invited to apply for the spring selection 2012. Deadline for application is January 15th, 2012. > All students accepted to the program will receive a generous PhD fellowship covering tuition and living expenses. > Further information and application details are available at: www.imprs-ls.de<http://www.imprs-ls.de/> > > We kindly ask you to communicate this announcement to potentially interested students or to display the flyer at your departmental bulletin board. > > > Yours sincerely, > > Ingrid Wolf > > __________________________________________________________________________________________ > Dr. Ingrid Wolf > Scientific Coordinator > International Max Planck Research School > for Molecular and Cellular Life Sciences > Am Klopferspitz 18 > 82152 Martinsried/Munich, Germany > phone: ++49 89 8578-2855 (Wed., Thu., Fri.) > fax: ++49 89 8578-2859 > email: inwolf(a)biochem.mpg.de > web: www.imprs-ls.de > > If you don't want to receive further mails from IMPRS-LS, please send us a reply email with the note "sign out" in the header. > > -- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Director, California Institute for Quantitative Biosciences at UCSF Department of Pharmaceutical Chemistry University of California at San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org

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[Compbio-allhands] Fwd: help please in idenifying a candidate
by Brian Shoichet 18 Oct '11

18 Oct '11

FYI. ---------- Forwarded message ---------- From: Chandra Verma <chandra(a)bii.a-star.edu.sg> Date: Tue, Oct 18, 2011 at 3:11 AM Subject: help please in idenifying a candidate To: Brian Shoichet <shoichet(a)cgl.ucsf.edu> dear brian hope all is well. i need your help in identifying a suitable candidate - given that yours is one of the few places that combines computational with experimental. we have an opening for a person with 4-5 years postdoctoral experience to set up a small lab here in our institute in singapore. here is the ad i am planning on putting out. many thanks for your help and if you could suggest some other labs i could write to, will be much obliged. regards chandra A position is available for a team leader with a background in chemical biology to start a small group combining computational and experimental methods for screening small molecules against targets of therapeutic interest. The person will have at least 5-6 years of postdoctoral experience in this area. The institute has a variety of teams pursuing computational studies combining them with experimental work. The candidate will be expected to develop their own research program as well as work with other teams in setting up assays to test hypotheses generated. There are several opportunities to collaborate with academic, pharmaceutical and clinical groups in Singapore. The position will be in the Division of Modelling & Design in the Bioinformatics Institute (A*STAR) (http://www.bii.a-star.edu.sg/**research/bmad/bmad.php<http://www.bii.a-star.edu.sg/research/bmad/bmad.php> ). Please submit a resume and a research proposal and have 3 letters of reference sent to bettyk(a)bii.a-star.edu.sg and to chandra(a)bii.a-star.edu.sg. Informal enquiries may be made from chandra(a)bii.a-star.edu.sg -- Brian Shoichet Professor University of California, San Francisco Dept. of Pharmaceutical Chemistry phone: 415-514-4126; fax: 415-514-4260 http://shoichetlab.compbio.ucsf.edu

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[Compbio-allhands] Fwd: I have money for excellent semi-independent position for post-postdoc for a few years
by Andrej Sali 18 Oct '11

18 Oct '11

Begin forwarded message: > From: Burkhard Rost <rost(a)in.tum.de> > Subject: I have money for excellent semi-independent position for post-postdoc for a few years > Date: October 18, 2011 5:06:53 AM PDT > To: Schneider Reinhard <reinhard.schneider(a)uni.lu>, Kelso Janet <kelso(a)eva.mpg.de>, Bromberg Yana <YanaB(a)rci.rutgers.edu>, Michal Linial <michall(a)cc.huji.ac.il>, Ofran Yanay <yanay.ofran(a)gmail.com>, Ben-Tal Nir <NirB(a)tauex.tau.ac.il>, Schlessinger Avner <schles(a)salilab.org>, Sali Andrej <sali(a)salilab.org>, Lupas Andrei <andrei.lupas(a)tuebingen.mpg.de>, Sippl Manfred <sippl(a)came.sbg.ac.at>, Orengo Christine <orengo(a)biochemistry.ucl.ac.uk>, Valencia Alfonso <valencia(a)cnio.es>, Tramontano Anna <Anna.Tramontano(a)uniroma1.it>, Punta Marco <mp13(a)sanger.ac.uk>, Gaasterland Terry <tgaasterland(a)ucsd.edu> > > Dear Friends: > > I have funding for the position that Marco Punta just left in April this year to join Pfam. The official position is as Fellow ("for life" with funding for <3 years; official 'title' Carl von Linde Fellow: mind you is one those who helped toward inventing the fridge and one of those scientists who went out and made money) of the Institute of Advanced Studies @ the TUM. It comes with a lot of freedom, high visibility, and fair funding. Applicants would have to be in Germany most of the time and would be expected to use this as a jump board to find a tenure-track position somewhere. > > Any of you has any proposal? Ideally, I'd like to find a woman for this, because those are very much underrepresented in the list of current fellows. > > As always, this is unfortunately very urgent (application deadline: Nov 1). > > thanks for your help. > best wishes, > burkhard > > -- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Director, California Institute for Quantitative Biosciences at UCSF Department of Pharmaceutical Chemistry University of California at San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org

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compbio-allhands October 2011