January 2015 - compbio-allhands@cgl.ucsf.edu

[Compbio-allhands] Fwd: postdoc opening
by Jacobson, Matt 08 Jan '15

08 Jan '15

Begin forwarded message: From: "Jansen, Johanna" <johanna.jansen(a)novartis.com<mailto:johanna.jansen@novartis.com>> Subject: postdoc opening Date: January 8, 2015 4:55:49 PM PST To: "'Matt.Jacobson(a)ucsf.edu<mailto:Matt.Jacobson@ucsf.edu>'" <Matt.Jacobson(a)ucsf.edu<mailto:Matt.Jacobson@ucsf.edu>>, "shoichet(a)cgl.ucsf.edu<mailto:shoichet@cgl.ucsf.edu>" <shoichet(a)cgl.ucsf.edu<mailto:shoichet@cgl.ucsf.edu>> Dear Matt & Brian, It was good seeing you at the event today. Below is the summary of the postdoc position that is opening in our group. I will be the mentor and Heinz Moser will be co-mentor. I would appreciate it if you could advertise this at UCSF and I’ll be happy to speak with any interested graduate students to provide further information. Thanks ! Hanneke New in silico descriptors for correlations with biological endpoints and drug design principles: The Computer-Aided Drug Discovery (CADD) group has a strong focus on utilizing the vast Novartis knowledgebase to extract relationships between properties of molecules and their biological activity, and on developing approaches to make predictions based on those relationships using properties calculated from chemical structure (in silico descriptors). We work closely with experimentalists to design the compound sets for measurements of biological and physical properties in an effort to drive drug discovery and determine which molecular properties we can calculate that are predictive of the experimental properties. Two molecular properties that are not well described by the in silico descriptors commonly used in drug discovery are conformational flexibility and hydrogen-bonding strength. These properties play an important role in many biological activities, including various aspects of permeability (entry into mammalian cells, entry into gram-negative pathogens, blood-brain-barrier penetration, and passage across epithelial barriers). In order to better guide chemistry designs in drug discovery, we need better in silico descriptors to capture flexibility and hydrogen bonding strength. Our platform brings together computational, medicinal, and analytical chemistry, with the scientists that measure the relevant physicochemical and biological properties. This environment of experts, software, instruments, and data is particularly suited to develop new approaches for predicting these properties, including creating experimental datasets, and developing and evaluating new in silico descriptors. Applications of such descriptors include selection efforts (archive enhancement, library design, screening set design) as well as prospective chemistry designs during optimization. Qualifications: PhD degree holders, and PhD students within one year of completing of their degrees are eligible to apply. For more information, contact Hanneke Jansen at Johanna.Jansen(a)novartis.com<mailto:Johanna.Jansen@novartis.com>. To download the cover letter template and apply, please visit http://postdoc.nibr.com/ Matthew P. Jacobson Professor, Department of Pharmaceutical Chemistry Department of Bioengineering and Therapeutic Sciences California Institute for Quantitative Biosciences Institute for Neurodegenerative Diseases Director, Graduate Group in Biophysics UCSF MC 2540 1700 4th St., Byers Hall, Room 408E San Francisco, CA 94158-2330 matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu> jacobsonlab.org<http://jacobsonlab.org>

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[Compbio-allhands] Murcko talk at noon
by Jacobson, Matt 08 Jan '15

08 Jan '15

A reminder that Mark Murcko is giving the Kollman lecture today at noon, on free energy calculations in drug discovery. Hope to see a good turnout -- Matt Sent from my iPhone

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[Compbio-allhands] Fwd: Bioinformatics/biostats positions at Roche Sequencing
by Andrej Sali 05 Jan '15

05 Jan '15

-- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Department of Pharmaceutical Chemistry California Institute for Quantitative Biosciences University of California, San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org > Begin forwarded message: > > From: "Chaivorapol, Christina" <christina.chaivorapol(a)roche.com> > Date: January 5, 2015 at 10:59:48 AM PST > Subject: Bioinformatics/biostats positions at Roche Sequencing > To: Andrej Sali <sali(a)salilab.org> > > Hi Andrej, > > Happy new year! I hope things are well with you. I'm not sure if you heard, but I moved to Roche Sequencing to build a bioinformatics group that will focus on developing diagnostics based on NGS technology. I am currently looking to fill a few positions in my group and hope you will be able to forward this to people in your lab and/or at UCSF who might be interested in these jobs. > > Attached are the job postings for the positions in my group. If anyone is interested, please have them apply to the position of interest at the following links: > > Principal Scientist <http://www.roche.com/careers/jobs/jobsearch/job.htm?id=E-3017264312&locale=…> > Senior Biostatistican <http://www.roche.com/careers/jobs/jobsearch/job.htm?id=E-3017264212&locale=…> > > Thanks, > Christina > -- > Christina Chaivorapol, Ph.D. > Research Leader, Bioinformatics > > Roche Sequencing > Bioinformatics > 4300 Hacienda Dr. > Pleasanton, CA 94588 > Email: christina.chaivorapol(a)roche.com <mailto:christina.chaivorapol@roche.com> > Phone: +1 925-474-7343 > Fax: +1 925-730-8988 > > Confidentiality Note: This message is intended only for the use of the named recipient(s) and may contain confidential and/or proprietary information. If you are not the intended recipient, please contact the sender and delete this message. Any unauthorized use of the information contained in this message is prohibited. >

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