December 2021 - compbio-allhands@cgl.ucsf.edu

[Compbio-allhands] Neomorph job opportunity
by Andrej Sali 18 Dec '21

18 Dec '21

https://careers-neomorph.icims.com/jobs/1666/data-scientist-ii%2c-molecular… <https://careers-neomorph.icims.com/jobs/1666/data-scientist-ii,-molecular-m…> -- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Associate Dean for Research, School of Pharmacy Department of Pharmaceutical Chemistry California Institute for Quantitative Biosciences University of California, San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94143, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Administrative Assistant: Steve Ha, assistant(a)salilab.org, Tel +1 (415) 514-4228, 502-8084 Email sali(a)salilab.org; Web http://salilab.org

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[Compbio-allhands] 1/6/22 BBC Seminar with Feng Zhang, PhD, Noon
by Flowers, Nicole 16 Dec '21

16 Dec '21

BBC Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursdays, Noon Zoom: http://tiny.ucsf.edu/pUYmCK Please do not share this link outside of UCSF Feng Zhang, PhD MIT Exploration of Biological Diversity January 6, 2022 P. Klauser & W. Shen, Hosts BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. Subscribe to the BBC Seminar Series Calendar! Use this URL to access this calendar from a web browser.<https://urldefense.com/v3/__https://calendar.google.com/calendar/embed?src=… > Use this address to access this calendar from other applications.<https://urldefense.com/v3/__https://calendar.google.com/calendar/u/1?cid=cz… > Use this URL to view and open the calendar in iCal and/or Outlook.<https://urldefense.proofpoint.com/v2/url?u=https-3A__ucsf.us20.list-2Dmanag…> To view recorded lectures, click here: https://lecture.ucsf.edu/ets/Channel/0671978c87c64a7db9251cff75b922505f

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[Compbio-allhands] Fwd: Open Postdoc Positon
by Michael Keiser 09 Dec '21

09 Dec '21

---------- Forwarded message --------- From: Colin Smith <colin.smith(a)wesleyan.edu> Date: Thu, Dec 9, 2021 at 12:50 PM Subject: Open Postdoc Positon To: Colin Smith <colin.smith(a)wesleyan.edu> Dear Colleagues, I have a postdoc position currently open in my group to develop and apply computational techniques for refining NMR structures. I would appreciate it if you would distribute the description below to your lab members or colleagues that may know suitable candidates. Thanks and happy holidays! Colin Colin A. Smith Assistant Professor Department of Chemistry Wesleyan University +1 860 685-3274 http://smithlab.wesleyan.edu The Smith Lab at Wesleyan University has an immediate opening for a postdoc (http://smithlab.research.wesleyan.edu/joining) Our lab specializes in developing and applying methods for computationally modeling NMR data. We use these and other techniques to study dynamics of computationally designed proteins and allostery in natural proteins. We have recently developed the Kinetic Ensemble theoretical framework that allows us to rigorously model how many types of motion affect the Nuclear Overhauser Effect (NOE), which is foundational to NMR-based structure determination. We have shown that approximations made in traditional NOE-based structure determination can result in significant underfitting of the data. We would like to now extend this methodology to enable direct refinement of highly accurate protein ensembles using leading biomolecular modeling software packages. We are seeking an individual with programming experience in a compiled language like C++ who will create and apply next-generation NOE restraints using the Kinetic Ensemble methodology. Together with advanced NOE peak integration using our FitNMR software package, the overall goal is to develop a fully quantitative pipeline to generate the most accurate solution ensembles of proteins to date. We hope this will advance the field of NMR structure determination and yield insights into how the solution state dynamics of proteins at the atomic level differ from those found in crystals. Suitable candidates are encouraged to contact Prof. Colin Smith ( colin.smith(a)wesleyan.edu) to apply and/or discuss this opportunity. Individuals having demonstrated experience with high-performance programming in the context of a large existing codebase are especially well-suited for this position. -- Michael J Keiser, PhD Associate Professor, UCSF p/1-415-886-7651 calendly.com/mjke

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