- compbio-allhands@cgl.ucsf.edu - RBVI Mailing Lists

[Compbio-allhands] 10/3/19 Seminar with Francois Diederich
by Flowers, Nicole 24 Sep '19

24 Sep '19

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursday, 4 PM **SPECIAL TIME** Genentech Hall N114 Livestream: http://tiny.ucsf.edu/1L7qxA Francois Diederich ETH Zurich Novartis Lecture: Molecular Recognition in Chemical and Biological Systems: Chemical Models and Biostructural Investigations October 3, 2019 B. DeGrado, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. Nicole Takesono Flowers Biophysics Graduate Program Manager UCSF MC 2240 600 16th St. Genentech Hall Room N474D San Francisco, CA 94143 P: 415.502.6518

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[Compbio-allhands] Fwd: Post-doctoral position at Rice University, USA - please distribute
by Andrej Sali 24 Sep '19

24 Sep '19

> Begin forwarded message: > > From: Lydia Kavraki <kavraki(a)rice.edu> > Subject: Post-doctoral position at Rice University, USA - please distribute > Date: September 23, 2019 at 10:01:20 PM PDT > To: Lydia Kavraki <kavraki(a)cs.rice.edu> > Reply-To: Lydia Kavraki <kavraki(a)rice.edu> > > Dear Colleagues, > > I would be greateful if you could distribute the announcement below to your groups and institutions. > > With best wishes, > > Lydia Kavraki > > > Lydia E. Kavraki, Ph.D. > > Noah Harding Professor of Computer Science > Professor of Bioengineering > http://www.cs.rice.edu/~kavraki <http://www.cs.rice.edu/~kavraki> > http://www.kavrakilab.org <http://www.kavrakilab.org/> > > Director, Ken Kennedy Institute <https://k2i.rice.edu/> > Rice University > > > =================================== > > Rice University > > Postdoctoral Position in Bioinformatics and Computational Immunology > > The Kavraki Lab at Rice University (http://www.kavrakilab.org <http://www.kavrakilab.org/>) is seeking candidates to fill one postdoctoral position. The topic of the research relates to the development of computational methods to support novel cancer therapies and, in particular, personalized cancer immunotherapies. > > Developing effective cancer treatments remains one of the most important challenges for healthcare, and T-cell based immunotherapy has provided some very positive recent advances in cancer treatment. Cytotoxic T lymphocytes (CTLs) can circulate through the body and are capable of identifying and eliminating tumorigenic cells. The recognition of tumor depends on the specific interaction between the T-cell receptor of CTLs, and class I Human Leucocyte Antigen (HLA) receptors. HLA receptors bind peptides derived from intracellular proteins, and display them at the cell surface. These peptide-HLA complexes are present at the surface of virtually all nucleated cells, constituting an efficient surveillance mechanism by which the immune system can recognize aberrant changes within cells of the body. Although CTL surveillance likely evolved to eliminate virally-infected cells, this system now provides very promising opportunities for cancer treatment and specifically the development of immune-based therapies. The understanding of peptide-HLA interactions at scale presents a formidable problem and computational analysis has a huge role to play. The overall goal of our research is to develop novel algorithmic methodologies for the modeling and analysis of peptide-HLAs, and its recognition by CTLs, implementing these methodologies in toolkits that can be used by immunologists. Most of our research deals with structural methods but we do complement our analyses with sequence methods. > > The individual recruited to fill this position will be working closely with collaborators at the MD Anderson Cancer Center and other researchers at the Texas Medical Center, the largest medical complex in the world. > > BACKGROUND: Applicants must hold a Ph.D. in Computer Science, Bioinformatics, Biomedical Informatics, or a related field. Prior knowledge of immunology is not required, but it is desirable. Familiarity with bioinformatics databases and tools is also desirable. Applicants with Ph.D.s in the Biological Sciences will be considered if they have expertise in immunology and good computational skills. They must be willing to train in computer science. This position is particularly suited for candidates who want to follow a career in academia; the position can include formal training for obtaining and succeeding in an academic position, if the candidate desires so. > > DURATION: Postdoctoral fellows are eligible for up to two years of support. All re-appointments are dependent upon a satisfactory progress review and continued funding. > > ABOUT RICE UNIVERSITY: As a leading research university with a distinctive commitment to undergraduate education, Rice University (http://www.rice.edu <http://www.rice.edu/>) aspires to path breaking research, unsurpassed teaching, and contributions to the betterment of our world. It seeks to fulfill this mission by cultivating a diverse community of learning and discovery that produces leaders across the spectrum of human endeavor. Rice University, an equal opportunity employer and a Tier 1 Research University, is located in the vibrant urban setting of Houston, TX, the fourth largest city in the U.S. Rice is ranked No. 15 by Forbes, among the top research universities, and No. 16 on their list of 50 Best U.S. colleges for international students. > > ABOUT THE LAB: The Kavraki Lab (http://www.kavrakilab.org <http://www.kavrakilab.org/>) develops computational methods and tools to model protein structure and function, understand biomolecular interactions, aid the process of medicinal drug discovery, analyze the molecular machinery of the cell, and help integrate biological and biomedical data for improving human health. We employ computational techniques that range from robotics-inspired algorithms to machine learning and data science, and we work closely with researchers at the Texas Medical Center. The Lab provides a stimulating working environment and has excellent record placing postdocs in faculty positions. The Computer Science Department at Rice University is part of the Gulf Coast Consortia for Quantitative Biomedical Sciences (http://www.gulfcoastconsortia.org <http://www.gulfcoastconsortia.org/>), and offers an unparalleled training environment. > > Interested applicants should contact Professor Lydia Kavraki (kavraki(a)rice.edu <mailto:kavraki@rice.edu>) and provide a CV and a one paragraph statement about their interest in the advertised position. Please include the names of at least three references in the CV. > > The position is available immediately. > > > >

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[Compbio-allhands] Fwd: FW: Western New England Open Positions
by Tom Ferrin 18 Sep '19

18 Sep '19

-------- Forwarded Message -------- Subject: FW: Western New England Open Positions Date: Wed, 18 Sep 2019 16:44:59 +0000 From: Heather DeMar <heather.demar(a)wne.edu> To: tef(a)cgl.ucsf.edu <tef(a)cgl.ucsf.edu> Dear Dr. Ferrin, We were hoping that you could pass along to your post-doctoral fellows and PhD students about to graduate that the College of Pharmacy and Health Sciences at Western New England University has the following openings; Medicinal Chemistry faculty position and a Pharmacology faculty position. The position advertisement is attached but can also be found online at: https://wne.csod.com/ats/careersite/JobDetails.aspx?id=233&site=1 (Medicinal Chemistry) https://www.higheredjobs.com/search/details.cfm?JobCode=177096343&Title=Ass… (Pharmacology) Thank you very much for your help! Sincerely, Dan Daniel R. Kennedy Ph.D. Chair & Associate Professor Department of Pharmaceutical & Administrative Sciences Room 317 - Center for Sciences and Pharmacy College of Pharmacy and Health Sciences Western New England University 1215 Wilbraham Rd. Springfield, MA 01119-2684 (413)-796-2413

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[Compbio-allhands] Fwd: Rockefeller University Faculty Open Search
by Andrej Sali 09 Sep '19

09 Sep '19

> Begin forwarded message: > > From: Sean Brady <sbrady(a)mail.rockefeller.edu> > Subject: Rockefeller University Faculty Open Search > Date: September 9, 2019 at 10:03:31 AM PDT > To: Undisclosed recipients:; > > Dear Colleague, > > Under the leadership of our President, Richard P. Lifton, The Rockefeller University continues its effort to recruit outstanding new Heads of Laboratory. The right candidate will have a creative and rigorous research program and will be highly interactive with our small but exceptional research community. In return, The Rockefeller University is committed to fostering outstanding scientists through a superb research environment and resources to promote innovative research. > > We are writing to seek your help in identifying highly motivated, creative and innovative scientists working in any of the following major areas of research: > > - Biochemistry, Biophysics, Chemical Biology, and Structural Biology > - Cancer Biology > - Cell Biology > - Genetics and Genomics > - Neurosciences and Behavior > - Immunology, Virology, and Microbiology > - Organismal Biology and Evolution > - Mechanisms of Human Disease > - Physical, Mathematical, and Computational Biology > - Stem Cells, Development, Regeneration, and Aging > > The Search Committee would greatly appreciate your assistance in encouraging exceptional candidates to apply. We seek tenure-track faculty candidates possessing either a Ph.D. degree, M.D. degree, or both. We also welcome applicants from tenured scientists at an early stage of their career. Applications are being accepted electronically through our Online Application System at http://oas.rockefeller.edu. <http://oas.rockefeller.edu/> Our application deadline is October 1, 2019. > > We would also be grateful for your suggestions of specific candidates we should consider. We are especially interested in the names of any women or minority candidates. Please forward any recommendations you may have > to facultysearch(a)rockefeller.edu. <mailto:facultysearch@rockefeller.edu> > > Further information regarding our current search can be found in the attached advertisements and athttp://www.rockefeller.edu/facultysearch. <http://www.rockefeller.edu/facultysearch> > > We very much appreciate your help with this important effort. > > Best regards, > > Sean F. Brady > Chair, 2019-2020 Faculty Open Search Committee > Professor, Laboratory of Genetically Encoded Small Molecules > The Rockefeller University >

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[Compbio-allhands] Fwd: EMBL Cell Biology & Biophysics Group Leader recruitment 2019
by Andrej Sali 03 Sep '19

03 Sep '19

> Begin forwarded message: > > From: Jan Ellenberg <jan.ellenberg(a)embl.de> > Subject: EMBL Cell Biology & Biophysics Group Leader recruitment 2019 > Date: September 3, 2019 at 5:01:42 AM PDT > To: Andrej Sali <sali(a)salilab.org> > > Dear Andrej, > > I would like to draw your attention to the opening for a group leader position in the Cell Biology and Biophysics Unit at EMBL Heidelberg, as recently advertised in Nature and Science. > > We are looking for outstanding junior scientists with a background in biology, physics, chemistry, engineering or mathematics that want to pursue original and interdisciplinary research in cutting edge molecular cell biology and/or technology development in the areas of imaging technology and computational modelling of dynamic cell biological processes. > > Although there is no age range, we generally hire group leaders early in their careers, often after their first postdoc and sometimes immediately after their PhD. We therefore strongly encourage highly promising young and particularly also female candidates to apply. EMBL group leaders are provided with a very generous internal support package and a highly collaborative environment. > > I would very much appreciate if you could bring the attached advertisement to the attention of suitable candidates or let me know if I should contact them personally. > > Thanks so much for help with this recruitment, > > All the best, > Jan > > Jan Ellenberg > Cell Biology and Biophysics Unit > European Molecular Biology Laboratory (EMBL) > Meyerhofstr. 1 > D-69117 Heidelberg > Germany > > T +49-6221-387-8391 > jan.ellenberg(a)embl.de <mailto:jan.ellenberg@embl.de> > www <https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.embl.d…>.embl.de/research/units/cbb/ellenberg/index.html <https://eur03.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.embl.d…> > > > > > > >

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[Compbio-allhands] Fwd: Tenure Track Position in Computational Chemical Biology Available at Vanderbilt
by Brian Shoichet 01 Sep '19

01 Sep '19

FYI ---------- Forwarded message --------- From: Bachmann, Brian O <brian.bachmann(a)vanderbilt.edu> Date: Sun, Sep 1, 2019 at 1:03 PM Subject: Tenure Track Position in Computational Chemical Biology Available at Vanderbilt To: shoichet(a)cgl.ucsf.edu <shoichet(a)cgl.ucsf.edu> Dear Brian, My apologies for the multiple emails, here is the attachment. Best, Brian -- Brian Shoichet, Professor, UCSF *http://www.bkslab.org/contact.php <http://www.bkslab.org/contact.php>*

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[Compbio-allhands] Fwd: MSK Tenure-Track Faculty Position in Chemistry or Chemical Biology
by Tom Ferrin 22 Aug '19

22 Aug '19

-------- Forwarded Message -------- Subject: MSK Tenure-Track Faculty Position in Chemistry or Chemical Biology Date: Thu, 22 Aug 2019 20:41:34 +0000 From: marquezj(a)mskcc.org To: tef(a)cgl.ucsf.edu August 22, 2019 ThomasFerrin Professor Chemistry and Chemical Biology University of California, San Francisco San Francisco, CA 94158 *Re: Tenure-Track Faculty Position in Chemistry or Chemical Biology* Dear Professor Ferrin, I write to request your assistance in identifying innovative individuals for a tenure-track position in the Chemical Biology Program at the Memorial Sloan Kettering Cancer Center (MSK). We seek candidates with strong research accomplishments in organic chemistry or chemical biology and interests in bringing chemical approaches to bear upon problems at the interface with biomedical research, including basic and translational research and across all disease areas. MSK has a rich history in chemical research spanning over 70 years, and we are continuing our recent expansion in this area. We provide a unique and collaborative scientific environment, exceptional research facilities and resources, and generous startup packages. Faculty are eligible to hold appointments in and to recruit students from multiple outstanding graduate programs, including the Tri-Institutional PhD Program in Chemical Biology, Tri-Institutional MD-PhD Program, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell Graduate School of Medical Sciences. *The application deadline is October 15, 2019*. Interested candidates should visit https://facultysearch.ski.edu to access the online application and to obtain important information on required application materials and deadlines. Applicants must have a PhD degree in chemistry, biochemistry, chemical biology, or a closely related discipline, and a strong track record of scientific achievement. Women and minority candidates are encouraged to apply. A copy of the search advertisement is below. If you have anyone you believe would be interested in applying or if there is someone you would like to recommend, please feel free to contact me directly. Sincerely, ** *Derek S. Tan, PhD* Chairman, Member, and Tri-Institutional Professor Chemical Biology Program *Memorial Sloan Kettering Cancer Center* 1275 York Ave., New York, NY 10065 T: 646-888-2234 • F: 646-422-0416 • tand(a)mskcc.org • www.dstan.org Director, Tri-Institutional PhD Program in Chemical Biology T: 212-746-5267 • F: 212-746-8992 • chembio.triiprograms.org *Tenure-Track Faculty Position in Chemistry or Chemical Biology* *Memorial Sloan Kettering Cancer Center* Memorial Sloan Kettering Cancer Center (MSK) seeks innovative individuals for tenure-track positions at the Assistant Member or Associate Member level, or tenured positions at the Member (Professor) level, with strong research accomplishments in organic chemistry or chemical biology and interests in bringing chemical approaches to bear upon problems at the interface with biomedical research, including basic and translational research and across all disease areas. MSK offers a unique and collaborative scientific environment, exceptional research facilities and resources, and generous startup packages. Faculty are eligible to hold appointments in and to recruit graduate students from the Tri-Institutional PhD Program in Chemical Biology, Tri-Institutional MD-PhD Program, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell Graduate School of Medical Sciences. The first two programs are operated jointly with Weill Cornell Medical College and the Rockefeller University. Applicants must have a PhD degree in chemistry, biochemistry, chemical biology, or a closely related discipline, a strong track record of scientific achievement, and dedication to problems at the interface of chemistry and biology. Senior applicants must also have a strong history of successful mentorship and extramural funding. Women and minority candidates are strongly encouraged to apply. MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. *Application Deadline: October 15, 2019. Interested candidates should visit https://facultysearch.ski.edu to access the on-line faculty application. *Please visit the site as soon as possible, as it contains important information on the required application materials, including deadlines for submission of letters of reference. Inquiries may be sent to *Jocette Marquez*, Program Coordinator at *marquezj(a)mskcc.org* <mailto:marquezj@mskcc.org> or to *Prof. Derek Tan, Chairman, Chemical Biology Program* at *tand(a)mskcc.org* <mailto:tand@mskcc.org>. ===================================================================== Please note that this e-mail and any files transmitted from Memorial Sloan Kettering Cancer Center may be privileged, confidential, and protected from disclosure under applicable law. If the reader of this message is not the intended recipient, or an employee or agent responsible for delivering this message to the intended recipient, you are hereby notified that any reading, dissemination, distribution, copying, or other use of this communication or any of its attachments is strictly prohibited. If you have received this communication in error, please notify the sender immediately by replying to this message and deleting this message, any attachments, and all copies and backups from your computer.

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[Compbio-allhands] Talk Today @ 1:30 PM CVRI Rm 442 (Dr. Robin Betz (Dror lab/Stanford)
by Grabe, Michael 13 Aug '19

13 Aug '19

Hi everyone, Sorry for the last minute notice for some of you, but I wanted to let you know/remind you that Robin Betz from Ron Dror’s lab at Stanford is giving a talk today in CVRI: Who: Dr. Robin Betz (Stanford) Title: How effectively can adaptive sampling methods capture spontaneous ligand binding? Time: 1:30-2:30 PM, Today Tuesday, August 13 Location: CVRI 442 Please come join us! Please distribute to anyone that may find this interesting. Best Michael ---------------------------------------------------------- Michael Grabe Professor University of California, San Francisco Cardiovascular Research Institute Department of Pharmaceutical Chemistry 555 Mission Bay Blvd South, Room 452T, MC 3122 San Francisco, California 94143 415-502-2874 (office) 415-476-8173 (fax)

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[Compbio-allhands] Fwd: staff scientist position in computational ligand discovery at Frederick National Lab
by Brian Shoichet 02 Aug '19

02 Aug '19

FYI Brian Shoichet, Professor, UCSF latest science http://www.bkslab.org ---------- Forwarded message --------- From: Balius, Trent (NIH/NCI) [C] <trent.balius(a)nih.gov> Date: Fri, Aug 2, 2019, 8:27 AM Subject: staff scientist position in computational ligand discovery at Frederick National Lab To: bshoichet(a)gmail.com <bshoichet(a)gmail.com> Cc: trent.balius(a)gmail.com <trent.balius(a)gmail.com> Hi Brian, I am advertising for a staff scientist position to join my team (the RAS Computational Chemistry Team) at the NCI RAS Initiative and the Frederick National Lab. Our vision is to perform computational ligand discovery, using large-scale docking to screen hundreds of millions -- and counting -- of small molecules, for RAS inhibitors/modulators and to have a tight cycle of collaboration with the experimental groups here at the RAS Initiative. Here is the advertisement: https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leido… Now hiring: Scientist I! <https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leido…> leidosbiomed.csod.com PROGRAM DESCRIPTION The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research ... I would appreciate it if you could help spread the word by sharing the ad with people who might be interested. Thanks, Trent ======================================================= *Trent E Balius, PhD *(Contractor) Project Lead, RAS Computational Chemistry, Cancer Research Technology Program (CRTP) Frederick National Laboratory for Cancer Research Leidos Biomedical Research Inc. URL: http://docking.org/~tbalius ======================================

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[Compbio-allhands] Fwd: AstraZeneca - Computational Medicinal Chemistry early career job opening
by Jacobson, Matt 23 Jul '19

23 Jul '19

-- Matt Sent from my iPad Begin forwarded message: From: "Lamb, Michelle" <Michelle.Lamb(a)astrazeneca.com<mailto:Michelle.Lamb@astrazeneca.com>> Date: July 22, 2019 at 7:36:10 PM EDT To: "Lamb, Michelle" <Michelle.Lamb(a)astrazeneca.com<mailto:Michelle.Lamb@astrazeneca.com>> Subject: AstraZeneca - Computational Medicinal Chemistry early career job opening Dear Colleagues, I’d like to call your attention to an opening for an early career computational chemist to support oncology project teams at AstraZeneca in Waltham, MA. Please feel free to suggest that any outstanding candidates review the job description and apply via the link below: https://urldefense.proofpoint.com/v2/url?u=https-3A__astrazeneca.wd3.mywork… <https://urldefense.proofpoint.com/v2/url?u=https-3A__astrazeneca.wd3.mywork…> Best regards, Michelle Michelle Lamb Team Leader, Chemistry _____________________________________________________________________________________________ AstraZeneca Oncology R&D | Research & Early Development 35 Gatehouse Drive, Waltham, MA, 02451 T: +1 781 839 4401 michelle.lamb(a)astrazeneca.com ________________________________ Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.

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[Compbio-allhands] Fwd: job opening at PacBio
by Andrej Sali 06 Jul '19

06 Jul '19

> Begin forwarded message: > > From: Satwik Kamtekar <skamtekar(a)pacificbiosciences.com> > Subject: job opening at PacBio > Date: July 7, 2019 at 12:07:24 AM GMT+2 > To: Andrej Sali <sali(a)salilab.org> > > Dear Andrej, > > We are looking to hire a scientist with a macromolecular modeling background at PacBio. I have pasted the description below and would appreciate it if you could forward this email to any students or postdocs who you feel might be appropriate/interested. > > My best regards, > Satwik > > http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e… <http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e…> > > Position: Scientist, Structural Biology > Location: > Menlo Park, CA > Job Id: 1932 > # of Openings: 1 > > Pacific Biosciences is seeking a highly motivated macromolecular modeler for a position at the Scientist level. The candidate will work within an interdisciplinary team to model macromolecular complexes, enzyme variants and their interactions with nucleotide analogs. The candidate will be able to draw on data from a wide variety of sources including crystallography, kinetic characterization and single molecule studies. She or he will use these data to both help design experiments that test mechanistic hypotheses and to design variants with desirable sequencing properties. The individual will be working in a fast-paced environment interacting with scientists from a wide variety of backgrounds. The title will be based on the selected individual’s experiences and determined at the offer stage. > > Position Requirements: > · Education Requirement: PhD. > · More than 3 years of experience in a postdoctoral, biotechnology or pharmaceutical industrial role is a plus. > · Extensive experience with macromolecular modeling is required. > · Rosetta modeling software expertise is highly desirable. > · Experience with analyzing information in databases, curating databases is desired. > · Knowledge of protein design/folding principles would be beneficial. > · Ability to work on several projects simultaneously. > · Effective communication (written/verbal) and ability to work independently and collaboratively as part of a team are critical. > All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. > > To apply: Please include a cover letter with your application. Please answer the following questions at the end of the letter: > · Have you designed mutations using structural, biochemical and kinetic information? If yes, briefly describe. > · What molecular modeling software are you comfortable using? > · What was your PhD (and/or Postdoctoral) research on? > · What do you find interesting about protein engineering/design? > · Have you worked on protein:nucleic acid interactions? > · Are you comfortable writing scripts/querying databases? Please describe. > · What is the most interesting scientific problem you have dealt with so far? > > All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. > > http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e… <http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e…>

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[Compbio-allhands] Fwd: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard
by Jacobson, Matt 23 Jun '19

23 Jun '19

-- Matt Sent from my iPhone Begin forwarded message: From: AJ Campbell <arthurc(a)broadinstitute.org<mailto:arthurc@broadinstitute.org>> Date: June 20, 2019 at 3:52:29 PM EDT To: Matt.Jacobson(a)ucsf.edu<mailto:Matt.Jacobson@ucsf.edu> Cc: Emily Matson <ematson(a)broadinstitute.org<mailto:ematson@broadinstitute.org>> Subject: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard Hi Dr. Jacobson, I hope you're doing well! I wanted to reach out because I am looking to recruit two Computational Chemists and a Cheminformatician to join the Center for the Development of Therapeutics (CDoT) modeling group at the Broad Institute and would love to tap your network! These roles will play a critical role in supporting medicinal chemistry efforts to advance current therapeutic projects within CDoT through structure-based and ligand-based modeling approaches. Take a look at the exciting pipeline of projects we are working on: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org… <https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> Here are the links to the job descriptions: https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> Please let me know if you have any postdocs in your program that would be interested in one of these roles. I am happy to connect you with our recruiter, Emily Matson, to fill in the details - she can be reached at ematson(a)broadinstitute.org<mailto:ematson@broadinstitute.org>. Let me know if you have any questions and many thanks! Best, AJ Working at CDoT<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> - Broad Institute of MIT & Harvard Broadminded Blog: Alisha Caliman cuts across disciplines as a computational chemist<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> CDoT Publications<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> - CDoT's scientific leadership has an average of 15 years of Drug Discovery career experience and have advanced 32 compounds into the clinic. Together, they lead an organization of 80 research scientists and associates, 60% of whom have doctorates in relevant fields or areas of expertise. Arthur J Campbell, Ph.D. Group Leader, Senior Computational Chemist I _________________________________________ The Broad Institute of MIT and Harvard Center for the Development of Therapeutics Stanley Center for Psychiatric Research 415 Main Street, Cambridge, MA 02142 Tel 1-617-714-7372 Email ArthurC(a)BroadInstitute.org<mailto:ArthurC@BroadInstitute.org> https://urldefense.proofpoint.com/v2/url?u=http-3A__www.BroadInstitute.org&… <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.BroadInstitute.org&…>

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[Compbio-allhands] Fwd: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard
by Brian Shoichet 20 Jun '19

20 Jun '19

FYI ---------- Forwarded message --------- From: AJ Campbell <arthurc(a)broadinstitute.org> Date: Thu, Jun 20, 2019 at 12:32 PM Subject: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard To: <shoichet(a)cgl.ucsf.edu> Cc: Emily Matson <ematson(a)broadinstitute.org> Hi Dr. Shoichet, I hope you're doing well! I wanted to reach out because I am looking to recruit two Computational Chemists and a Cheminformatician to join the Center for the Development of Therapeutics (CDoT) modeling group at the Broad Institute and would love to tap your network! These roles will play a critical role in supporting medicinal chemistry efforts to advance current therapeutic projects within CDoT through structure-based and ligand-based modeling approaches. Take a look at the exciting pipeline of projects we are working on: https://www.broadinstitute.org/center-development-therapeutics/pipeline Here are the links to the job descriptions: https://broadinstitute.wd1.myworkdayjobs.com/broadinstitute_cdot/job/Cambri… https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Camb… https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Camb… Please let me know if you have any postdocs in your program that would be interested in one of these roles. I am happy to connect you with our recruiter, Emily Matson, to fill in the details - she can be reached at ematson(a)broadinstitute.org. Let me know if you have any questions and many thanks! Best, AJ *Working at CDoT <https://www.broadinstitute.org/center-development-therapeutics/working-cdot> - Broad Institute of MIT & Harvard* *Broadminded Blog:* *Alisha Caliman cuts across disciplines as a computational chemist* <https://www.broadinstitute.org/blog/alisha-caliman-cuts-across-disciplines-…> *CDoT Publications <https://www.broadinstitute.org/publications-list/1146>* *- CDoT's scientific leadership has an average of 15 years of Drug Discovery career experience and have advanced 32 compounds into the clinic. Together, they lead an organization of 80 research scientists and associates, 60% of whom have doctorates in relevant fields or areas of expertise.* *Arthur J Campbell, Ph.D.* Group Leader, Senior Computational Chemist I _________________________________________ *The Broad Institute of MIT and Harvard* Center for the Development of Therapeutics Stanley Center for Psychiatric Research 415 Main Street, Cambridge, MA 02142 Tel 1-617-714-7372 Email ArthurC(a)BroadInstitute.org www.BroadInstitute.org -- Brian Shoichet, Professor, UCSF *http://www.bkslab.org/contact.php <http://www.bkslab.org/contact.php>*

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[Compbio-allhands] Fwd: CADD job opportunity at NIBR-Emeryville (CA)
by Jacobson, Matt 12 Jun '19

12 Jun '19

— Matt Begin forwarded message: From: "Jansen, Johanna" <johanna.jansen(a)novartis.com<mailto:johanna.jansen@novartis.com>> Subject: CADD job opportunity at NIBR-Emeryville (CA) Date: June 11, 2019 at 3:46:39 PM PDT To: "matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>" <matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>> Dear Matt, I hope this message finds you well. I am writing to ask your help in recruiting. I have 2 openings in my group at NIBR-Emeryville (CA), one junior and one senior position. We are building up a department in Emeryville around our core expertise involving protein science, structure & biophysics, computational & medicinal chemistry. Our drug discovery focus will be on “targets in context”. The context for the targets includes other partner entities as well as the context of time (dynamics and kinetics). From a computational chemistry perspective, this means a focus on simulating large(r) multi-component complexes with the aim to understand mechanism and opportunity to modulate, including the design of novel therapeutics. From a computational medicinal chemistry perspective, a strategic focus will be on effective exploration of chemical space. This includes using multi-objective optimization combined with exceptional predictive modeling tools, generative chemistry, recommenders, and effective design cycles. I would very much appreciate your recommendations of potential candidates who have a passion for discovering drug candidates and who have skills in the area of macromolecular modeling & simulations and/or machine learning & data science. Experience in experimental structure & biophysics work or experimental medicinal chemistry would be an advantage (but not a requirement). Please let me know if you have anybody you would recommend I talk to for either the junior or the senior position. Feel free to share the link to the job description with potential candidates: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.novartis.com_caree… <https://urldefense.proofpoint.com/v2/url?u=https-3A__www.novartis.com_caree…> Thanks! Hanneke Johanna M. Jansen, PhD Head Computer-Aided Drug Discovery Emeryville Novartis Institutes for BioMedical Research Global Discovery Chemistry Emeryville 5300 Chiron Way CA 94608 Emeryville United States of America

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[Compbio-allhands] Fwd: CADD job opportunity at NIBR-Emeryville (CA)
by Andrej Sali 12 Jun '19

12 Jun '19

> Begin forwarded message: > > From: "Jansen, Johanna" <johanna.jansen(a)novartis.com> > Subject: CADD job opportunity at NIBR-Emeryville (CA) > Date: June 11, 2019 at 3:53:36 PM PDT > To: "sali(a)salilab.org" <sali(a)salilab.org> > > Dear Andrej, > > I hope this message finds you well. I am writing to ask your help in recruiting. I have 2 openings in my group at NIBR-Emeryville (CA), one junior and one senior position. > > We are building up a department in Emeryville around our core expertise involving protein science, structure & biophysics, computational & medicinal chemistry. Our drug discovery focus will be on “targets in context”. The context for the targets includes other partner entities as well as the context of time (dynamics and kinetics). From a computational chemistry perspective, this means a focus on simulating large(r) multi-component complexes with the aim to understand mechanism and opportunity to modulate, including the design of novel therapeutics. From a computational medicinal chemistry perspective, a strategic focus will be on effective exploration of chemical space. This includes using multi-objective optimization combined with exceptional predictive modeling tools, generative chemistry, recommenders, and effective design cycles. > > I would very much appreciate your recommendations of potential candidates who have a passion for discovering drug candidates and who have skills in the area of macromolecular modeling & simulations and/or machine learning & data science. Experience in experimental structure & biophysics work or experimental medicinal chemistry would be an advantage (but not a requirement). Please let me know if you have anybody you would recommend I talk to for either the junior or the senior position. Feel free to share the link to the job description with potential candidates: > https://www.novartis.com/careers/career-search/job-details/269776BR <https://www.novartis.com/careers/career-search/job-details/269776BR> > > Thanks! > Hanneke > > > > Johanna M. Jansen, PhD > Head Computer-Aided Drug Discovery Emeryville > > T +1 510 879 9548 > Johanna.jansen(a)novartis.com <mailto:Johanna.jansen@novartis.com> > > Novartis Institutes for BioMedical Research > Global Discovery Chemistry > Emeryville > 5300 Chiron Way > CA 94608 Emeryville > United States of America

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[Compbio-allhands] 5/30/19 Seminar with David Liu
by Flowers, Nicole 24 May '19

24 May '19

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursdays, 12 Noon Genentech Hall Auditorium Livestream: http://tiny.ucsf.edu/TATvuI David Liu Harvard Base editing: chemistry on a target base in the genome of living cells May 30, 2019 S. Elledge & J. Stevenson, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. -- Nicole Takesono Flowers BMI, BP, CCB, & PSPG Graduate Program Assistant UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94143 P: 415.502.6518

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[Compbio-allhands] Fwd: Imperial College Life Sciences Recruitment - Up to 8 Academic Staff positions
by Andrej Sali 20 May '19

20 May '19

-- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Associate Dean for Research, School of Pharmacy Department of Pharmaceutical Chemistry California Institute for Quantitative Biosciences University of California, San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94143, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Administrative Assistant: Steve Ha, assistant(a)salilab.org, Tel +1 (415) 514-4228, 502-8084 Email sali(a)salilab.org; Web http://salilab.org > Begin forwarded message: > > From: "Sternberg, Michael J E" <m.sternberg(a)imperial.ac.uk> > Subject: FW: Imperial College Life Sciences Recruitment - Up to 8 Academic Staff positions > Date: May 20, 2019 at 12:30:25 PM PDT > > > > Dear Colleague > > I would be grateful if you would advertise this opportunity / apply yourself. > > Thanks > > Mike Sternberg > -------------------------------------------------------------- > > The Department of Life Sciences at Imperial College is seeking applications for up to eight academic staff positions (tenure track where appropriate) starting in the 2019-20 academic year. One post is affiliated to the MRC Centre for Molecular Bacteriology and Infection (MRC-CMBI), which is located at the South Kensington Campus. > > The adverts are live and open for applications on the College website (links below) and will also be live on jobs.ac.uk <http://jobs.ac.uk/> and Nature by the end of the week. > > Reader / Chair <http://www.imperial.ac.uk/jobs/description/NAT00454/reader-or-chair> > Lecturer / Senior Lecturer <http://www.imperial.ac.uk/jobs/description/NAT00452/lecturer-senior-lecturer> > Lecturer / Senior Lecturer (MRC Centre for Molecular Bacteriology and Infection) <http://www.imperial.ac.uk/jobs/description/NAT00460/lecturer-senior-lecture…> > > Closing date: Monday 24 June 2019 > > The positions are open to outstanding candidates at all levels of seniority whose research and teaching is focused on seeking solutions for industrial and global challenges across the full breadth of Life Sciences. Appointees are expected to broaden the Department’s research capabilities, while complementing our existing strengths (https://www.imperial.ac.uk/life-sciences/research/research-themes/ <https://www.imperial.ac.uk/life-sciences/research/research-themes/>). > > We especially welcome applicants who are female or from other under-represented groups. > > Informal enquires for Bioinformatics & Theoretical Systems Biology can be made tom.sternberg(a)imperial.ac.uk <mailto:m.sternberg@imperial.ac.uk>. > General enquiries can be made to Professor Bernadette Byrne (b.byrne(a)imperial.ac.uk <mailto:b.byrne@imperial.ac.uk>) Professor Anne Dell (a.dell(a)imperial.ac.uk <mailto:a.dell@imperial.ac.uk>) and Professor Alain Filloux (a.filloux(a)imperial.ac.uk <mailto:a.filloux@imperial.ac.uk>) for the MRC-CMBI post. >

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[Compbio-allhands] Fwd: ProLynx Job Announcement
by Andrej Sali 15 May '19

15 May '19

two jobs at the local biotech > Begin forwarded message: > > From: Charles Garrett <chasgarrett(a)icloud.com> > Subject: ProLynx Job Announcement > Date: May 15, 2019 at 1:05:32 PM PDT > To: Andrej Sali <sali(a)salilab.org> > > Hi Andrej, > > ProLynx has a full-time opening for a protein chemist. Would you mind posting these two job announcements in your department? They look the same, but one is for a Ph.D., the other is for a BA. > > Also, please pass them on to anyone else you think might be interested. Thanks. > > I hope all is well with you. > > Regards, > Charles > > > > >

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[Compbio-allhands] Fwd: postdoc position
by Hao Li 09 May '19

09 May '19

-------- Forwarded Message -------- Subject: postdoc position Date: Fri, 10 May 2019 00:53:02 +0000 From: Wang, Wei <wei-wang(a)ucsd.edu> To: haoli(a)genome.ucsf.edu <haoli(a)genome.ucsf.edu> Computational biology postdoc at UCSD A postdoc position will be available in Wei Wang's group (http://wanglab.ucsd.edu) at UCSD. Our group is interested in developing novel machine learning methods for integrative analysis of epigenomic data and single cell data, and discovering new biological principles. Our research ranges from understanding fundamental biological mechanisms to applying epigenomics to identify new drug targets and biomarkers. Our lab consists of both computational and experimental experts. We have also collaborated closely with various labs and clinicians specialized in various diseases. We are looking for candidates who are interested in developing new algorithm to analyze big genomic and epigenomic data. An ideal candidate should be highly motivated, have profound knowledge of machine learning and statistics or solid training in other quantitative sciences such as physics and engineering. Proficient programming skills are essential. Previous experience of analyzing genomic or epigenomic data is a plus. Interested applicants should send CV and statement of research to wei-wang(a)ucsd.edu. Please also arrange three letters of recommendation sent directly to the above email address.

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[Compbio-allhands] 5/16/19 Seminar with Katherine Henzler-Wildman
by Flowers, Nicole 09 May '19

09 May '19

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursdays, 12 Noon Genentech Hall Auditorium Livestream: http://tiny.ucsf.edu/TATvuI Katherine Henzler-Wildman University of Wisconsin Re-thinking the transport mechanism of the small multidrug efflux pump, EmrE: Does promiscuity preclude tight coupling? May 16, 2019 A. Manglik, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. -- Nicole Takesono Flowers BMI, BP, CCB, & PSPG Graduate Program Assistant UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94143 P: 415.502.6518

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[Compbio-allhands] appliation field scientist at Dassault Inc
by Andrej Sali 08 May '19

08 May '19

> Begin forwarded message: > > From: YAN Lisa <Lisa.YAN(a)3ds.com> > Subject: congratulations > Date: May 8, 2019 at 11:18:08 AM PDT > To: Andrej Sali <sali(a)salilab.org> > Cc: RAMAN Prabhu <Prabhu.RAMAN(a)3ds.com>, LUU Tien <Tien.LUU(a)3ds.com> > > Hi Andrej, > > BTW, we have an open position for application field scientist: > https://careers.3ds.com/jobs/biovia-%E2%80%93-solution-consultant-ph-d-pre-… <https://careers.3ds.com/jobs/biovia-%E2%80%93-solution-consultant-ph-d-pre-…> > > If you know anyone who is looking for a job, could you please kindly forward? > > Thanks a lot, > > Lisa > This email and any attachments are intended solely for the use of the individual or entity to whom it is addressed and may be confidential and/or privileged. > If you are not one of the named recipients or have received this email in error, > (i) you should not read, disclose, or copy it, > (ii) please notify sender of your receipt by reply email and delete this email and all attachments, > (iii) Dassault Systèmes does not accept or assume any liability or responsibility for any use of or reliance on this email. > > Please be informed that your personal data are processed according to our data privacy policy as described on our website. Should you have any questions related to personal data protection, please contact 3DS Data Protection Officer at 3DS.compliance-privacy(a)3ds.com <mailto:3DS.compliance-privacy@3ds.com> > > For other languages, go to https://www.3ds.com/terms/email-disclaimer <https://www.3ds.com/terms/email-disclaimer>

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[Compbio-allhands] 5/9/19 Seminar with Ibrahim Cisse
by Flowers, Nicole 02 May '19

02 May '19

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursdays, 12 Noon Genentech Hall Auditorium Livestream: http://tiny.ucsf.edu/TATvuI Ibrahim Cissé MIT Super-resolution imaging of transcription in live mammalian cells May 9, 2019 G. Lewis, Host BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. -- Nicole Takesono Flowers BMI, BP, CCB, & PSPG Graduate Program Assistant UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94143 P: 415.502.6518

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[Compbio-allhands] Fwd: Structural Biology Postdoctoral Fellow
by Andrej Sali 01 May '19

01 May '19

> Begin forwarded message: > > From: "Fesik, Stephen" <stephen.fesik(a)Vanderbilt.Edu> > Subject: Structural Biology Postdoctoral Fellow > Date: April 30, 2019 at 9:02:55 AM PDT > To: Andrej Sali <sali(a)salilab.org> > > Dear Andrej, > > I am writing to ask your assistance in identifying talented and highly accomplished structural biologists with a desire to join our group as a postdoctoral fellow. > > My lab is a multidisciplinary team, comprised of structural biologists, medicinal chemists, and cell biologists, committed to discovering and developing novel therapeutics for the treatment of cancer. We use fragment-based methods and structure-based design to discover small molecule inhibitors for highly validated oncology targets such as K-Ras, Mcl-1, and WDR5 (Please see: https://lab.vanderbilt.edu/fesik-lab/ <https://lab.vanderbilt.edu/fesik-lab/>). > > Postdocs in our group will have the opportunity to learn and apply cutting edge fragment-based methods and structure-based approaches to design analogs of hit molecules to improve binding affinities. The close collaborations between synthetic chemists, cancer biologists, and structural biologists in our group will provide excellent training in drug discovery in a team environment. > > The ideal candidate will have a Ph.D. in NMR or X-ray crystallography with experience in the cloning and purification of proteins for structure determination. If you have a student that fits these criteria, please have them provide a cover letter describing their relevant experience, a curriculum vitae, and a short research summary of their work to stephen.fesik(a)vanderbilt.edu <mailto:stephen.fesik@vanderbilt.edu>. > > If you know of a colleague that may have an interested student, please feel free to forward this contact info to them as well. > > Sincerely, > Steve > > Stephen W. Fesik, Ph.D. > Professor of Biochemistry, Pharmacology, and Chemistry > Orrin H. Ingram, II Chair in Cancer Research > Vanderbilt University School of Medicine > 2215 Garland Ave, 607 Light Hall > Nashville, TN 37232-0146 > > Office: 634 RRB > Phone: (615) 322-6303 > Fax: (615) 875-3236 > Email: stephen.fesik(a)vanderbilt.edu <mailto:stephen.fesik@vanderbilt.edu> > Website: Fesik Lab <http://www.mc.vanderbilt.edu/fesiklab> > > >

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[Compbio-allhands] 5/2/19 Seminar with Kabirul Islam
by Flowers, Nicole 24 Apr '19

24 Apr '19

BBC Graduate Programs Seminar Series Bioinformatics Biophysics Chemistry & Chemical Biology Complex Biological Systems Thursdays, 12 Noon Genentech Hall Auditorium Livestream: http://tiny.ucsf.edu/TATvuI Kabirul Islam University of Pittsburgh Protein and Small Molecule Engineering towards an Orthogonal Chromatin Landscape May 2, 2019 M. Arkin & D. Fujimori, Hosts BBC Seminars are supported by the Biophysics, Bioinformatics, and Chemistry & Chemical Biology IFM, Department of Pharmaceutical Chemistry, QBC, HARC Center, and the Center for Systems and Synthetic Biology, and the Gladstone Center for Cell Circuitry. -- Nicole Takesono Flowers BMI, BP, CCB, & PSPG Graduate Program Assistant UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94143 P: 415.502.6518

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[Compbio-allhands] Yurii Moroz on Enamine speaking Friday April 12, 9:30 am BH-536A
by John Irwin 07 Apr '19

07 Apr '19

Dear Allhands Yurii Moroz of Enamine/REAL fame and a co-author on our recent Nature paper will speak about recent developments in purchasable chemical space and other topics. Date: Friday April 12 Time: 9:30 am Place: BH-536A See attachment. John

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