- compbio-allhands@cgl.ucsf.edu - RBVI Mailing Lists

[Compbio-allhands] Fwd: Tenure Track Position in Computational Chemical Biology Available at Vanderbilt
by Brian Shoichet 01 Sep '19

01 Sep '19

FYI ---------- Forwarded message --------- From: Bachmann, Brian O <brian.bachmann(a)vanderbilt.edu> Date: Sun, Sep 1, 2019 at 1:03 PM Subject: Tenure Track Position in Computational Chemical Biology Available at Vanderbilt To: shoichet(a)cgl.ucsf.edu <shoichet(a)cgl.ucsf.edu> Dear Brian, My apologies for the multiple emails, here is the attachment. Best, Brian -- Brian Shoichet, Professor, UCSF *http://www.bkslab.org/contact.php <http://www.bkslab.org/contact.php>*

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[Compbio-allhands] Fwd: MSK Tenure-Track Faculty Position in Chemistry or Chemical Biology
by Tom Ferrin 22 Aug '19

22 Aug '19

-------- Forwarded Message -------- Subject: MSK Tenure-Track Faculty Position in Chemistry or Chemical Biology Date: Thu, 22 Aug 2019 20:41:34 +0000 From: marquezj(a)mskcc.org To: tef(a)cgl.ucsf.edu August 22, 2019 ThomasFerrin Professor Chemistry and Chemical Biology University of California, San Francisco San Francisco, CA 94158 *Re: Tenure-Track Faculty Position in Chemistry or Chemical Biology* Dear Professor Ferrin, I write to request your assistance in identifying innovative individuals for a tenure-track position in the Chemical Biology Program at the Memorial Sloan Kettering Cancer Center (MSK). We seek candidates with strong research accomplishments in organic chemistry or chemical biology and interests in bringing chemical approaches to bear upon problems at the interface with biomedical research, including basic and translational research and across all disease areas. MSK has a rich history in chemical research spanning over 70 years, and we are continuing our recent expansion in this area. We provide a unique and collaborative scientific environment, exceptional research facilities and resources, and generous startup packages. Faculty are eligible to hold appointments in and to recruit students from multiple outstanding graduate programs, including the Tri-Institutional PhD Program in Chemical Biology, Tri-Institutional MD-PhD Program, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell Graduate School of Medical Sciences. *The application deadline is October 15, 2019*. Interested candidates should visit https://facultysearch.ski.edu to access the online application and to obtain important information on required application materials and deadlines. Applicants must have a PhD degree in chemistry, biochemistry, chemical biology, or a closely related discipline, and a strong track record of scientific achievement. Women and minority candidates are encouraged to apply. A copy of the search advertisement is below. If you have anyone you believe would be interested in applying or if there is someone you would like to recommend, please feel free to contact me directly. Sincerely, ** *Derek S. Tan, PhD* Chairman, Member, and Tri-Institutional Professor Chemical Biology Program *Memorial Sloan Kettering Cancer Center* 1275 York Ave., New York, NY 10065 T: 646-888-2234 • F: 646-422-0416 • tand(a)mskcc.org • www.dstan.org Director, Tri-Institutional PhD Program in Chemical Biology T: 212-746-5267 • F: 212-746-8992 • chembio.triiprograms.org *Tenure-Track Faculty Position in Chemistry or Chemical Biology* *Memorial Sloan Kettering Cancer Center* Memorial Sloan Kettering Cancer Center (MSK) seeks innovative individuals for tenure-track positions at the Assistant Member or Associate Member level, or tenured positions at the Member (Professor) level, with strong research accomplishments in organic chemistry or chemical biology and interests in bringing chemical approaches to bear upon problems at the interface with biomedical research, including basic and translational research and across all disease areas. MSK offers a unique and collaborative scientific environment, exceptional research facilities and resources, and generous startup packages. Faculty are eligible to hold appointments in and to recruit graduate students from the Tri-Institutional PhD Program in Chemical Biology, Tri-Institutional MD-PhD Program, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, and Weill Cornell Graduate School of Medical Sciences. The first two programs are operated jointly with Weill Cornell Medical College and the Rockefeller University. Applicants must have a PhD degree in chemistry, biochemistry, chemical biology, or a closely related discipline, a strong track record of scientific achievement, and dedication to problems at the interface of chemistry and biology. Senior applicants must also have a strong history of successful mentorship and extramural funding. Women and minority candidates are strongly encouraged to apply. MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. *Application Deadline: October 15, 2019. Interested candidates should visit https://facultysearch.ski.edu to access the on-line faculty application. *Please visit the site as soon as possible, as it contains important information on the required application materials, including deadlines for submission of letters of reference. Inquiries may be sent to *Jocette Marquez*, Program Coordinator at *marquezj(a)mskcc.org* <mailto:marquezj@mskcc.org> or to *Prof. Derek Tan, Chairman, Chemical Biology Program* at *tand(a)mskcc.org* <mailto:tand@mskcc.org>. ===================================================================== Please note that this e-mail and any files transmitted from Memorial Sloan Kettering Cancer Center may be privileged, confidential, and protected from disclosure under applicable law. If the reader of this message is not the intended recipient, or an employee or agent responsible for delivering this message to the intended recipient, you are hereby notified that any reading, dissemination, distribution, copying, or other use of this communication or any of its attachments is strictly prohibited. If you have received this communication in error, please notify the sender immediately by replying to this message and deleting this message, any attachments, and all copies and backups from your computer.

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[Compbio-allhands] Talk Today @ 1:30 PM CVRI Rm 442 (Dr. Robin Betz (Dror lab/Stanford)
by Grabe, Michael 13 Aug '19

13 Aug '19

Hi everyone, Sorry for the last minute notice for some of you, but I wanted to let you know/remind you that Robin Betz from Ron Dror’s lab at Stanford is giving a talk today in CVRI: Who: Dr. Robin Betz (Stanford) Title: How effectively can adaptive sampling methods capture spontaneous ligand binding? Time: 1:30-2:30 PM, Today Tuesday, August 13 Location: CVRI 442 Please come join us! Please distribute to anyone that may find this interesting. Best Michael ---------------------------------------------------------- Michael Grabe Professor University of California, San Francisco Cardiovascular Research Institute Department of Pharmaceutical Chemistry 555 Mission Bay Blvd South, Room 452T, MC 3122 San Francisco, California 94143 415-502-2874 (office) 415-476-8173 (fax)

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[Compbio-allhands] Fwd: staff scientist position in computational ligand discovery at Frederick National Lab
by Brian Shoichet 02 Aug '19

02 Aug '19

FYI Brian Shoichet, Professor, UCSF latest science http://www.bkslab.org ---------- Forwarded message --------- From: Balius, Trent (NIH/NCI) [C] <trent.balius(a)nih.gov> Date: Fri, Aug 2, 2019, 8:27 AM Subject: staff scientist position in computational ligand discovery at Frederick National Lab To: bshoichet(a)gmail.com <bshoichet(a)gmail.com> Cc: trent.balius(a)gmail.com <trent.balius(a)gmail.com> Hi Brian, I am advertising for a staff scientist position to join my team (the RAS Computational Chemistry Team) at the NCI RAS Initiative and the Frederick National Lab. Our vision is to perform computational ligand discovery, using large-scale docking to screen hundreds of millions -- and counting -- of small molecules, for RAS inhibitors/modulators and to have a tight cycle of collaboration with the experimental groups here at the RAS Initiative. Here is the advertisement: https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leido… Now hiring: Scientist I! <https://leidosbiomed.csod.com/ats/careersite/jobdetails.aspx?site=4&c=leido…> leidosbiomed.csod.com PROGRAM DESCRIPTION The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research ... I would appreciate it if you could help spread the word by sharing the ad with people who might be interested. Thanks, Trent ======================================================= *Trent E Balius, PhD *(Contractor) Project Lead, RAS Computational Chemistry, Cancer Research Technology Program (CRTP) Frederick National Laboratory for Cancer Research Leidos Biomedical Research Inc. URL: http://docking.org/~tbalius ======================================

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[Compbio-allhands] Fwd: AstraZeneca - Computational Medicinal Chemistry early career job opening
by Jacobson, Matt 23 Jul '19

23 Jul '19

-- Matt Sent from my iPad Begin forwarded message: From: "Lamb, Michelle" <Michelle.Lamb(a)astrazeneca.com<mailto:Michelle.Lamb@astrazeneca.com>> Date: July 22, 2019 at 7:36:10 PM EDT To: "Lamb, Michelle" <Michelle.Lamb(a)astrazeneca.com<mailto:Michelle.Lamb@astrazeneca.com>> Subject: AstraZeneca - Computational Medicinal Chemistry early career job opening Dear Colleagues, I’d like to call your attention to an opening for an early career computational chemist to support oncology project teams at AstraZeneca in Waltham, MA. Please feel free to suggest that any outstanding candidates review the job description and apply via the link below: https://urldefense.proofpoint.com/v2/url?u=https-3A__astrazeneca.wd3.mywork… <https://urldefense.proofpoint.com/v2/url?u=https-3A__astrazeneca.wd3.mywork…> Best regards, Michelle Michelle Lamb Team Leader, Chemistry _____________________________________________________________________________________________ AstraZeneca Oncology R&D | Research & Early Development 35 Gatehouse Drive, Waltham, MA, 02451 T: +1 781 839 4401 michelle.lamb(a)astrazeneca.com ________________________________ Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.

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[Compbio-allhands] Fwd: job opening at PacBio
by Andrej Sali 06 Jul '19

06 Jul '19

> Begin forwarded message: > > From: Satwik Kamtekar <skamtekar(a)pacificbiosciences.com> > Subject: job opening at PacBio > Date: July 7, 2019 at 12:07:24 AM GMT+2 > To: Andrej Sali <sali(a)salilab.org> > > Dear Andrej, > > We are looking to hire a scientist with a macromolecular modeling background at PacBio. I have pasted the description below and would appreciate it if you could forward this email to any students or postdocs who you feel might be appropriate/interested. > > My best regards, > Satwik > > http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e… <http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e…> > > Position: Scientist, Structural Biology > Location: > Menlo Park, CA > Job Id: 1932 > # of Openings: 1 > > Pacific Biosciences is seeking a highly motivated macromolecular modeler for a position at the Scientist level. The candidate will work within an interdisciplinary team to model macromolecular complexes, enzyme variants and their interactions with nucleotide analogs. The candidate will be able to draw on data from a wide variety of sources including crystallography, kinetic characterization and single molecule studies. She or he will use these data to both help design experiments that test mechanistic hypotheses and to design variants with desirable sequencing properties. The individual will be working in a fast-paced environment interacting with scientists from a wide variety of backgrounds. The title will be based on the selected individual’s experiences and determined at the offer stage. > > Position Requirements: > · Education Requirement: PhD. > · More than 3 years of experience in a postdoctoral, biotechnology or pharmaceutical industrial role is a plus. > · Extensive experience with macromolecular modeling is required. > · Rosetta modeling software expertise is highly desirable. > · Experience with analyzing information in databases, curating databases is desired. > · Knowledge of protein design/folding principles would be beneficial. > · Ability to work on several projects simultaneously. > · Effective communication (written/verbal) and ability to work independently and collaboratively as part of a team are critical. > All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities. > > To apply: Please include a cover letter with your application. Please answer the following questions at the end of the letter: > · Have you designed mutations using structural, biochemical and kinetic information? If yes, briefly describe. > · What molecular modeling software are you comfortable using? > · What was your PhD (and/or Postdoctoral) research on? > · What do you find interesting about protein engineering/design? > · Have you worked on protein:nucleic acid interactions? > · Are you comfortable writing scripts/querying databases? Please describe. > · What is the most interesting scientific problem you have dealt with so far? > > All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation. > > http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e… <http://www.pacb.com/company/careers/?gnk=job&gni=8a7887a96b7b7d75016b9b2b9e…>

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[Compbio-allhands] Fwd: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard
by Jacobson, Matt 23 Jun '19

23 Jun '19

-- Matt Sent from my iPhone Begin forwarded message: From: AJ Campbell <arthurc(a)broadinstitute.org<mailto:arthurc@broadinstitute.org>> Date: June 20, 2019 at 3:52:29 PM EDT To: Matt.Jacobson(a)ucsf.edu<mailto:Matt.Jacobson@ucsf.edu> Cc: Emily Matson <ematson(a)broadinstitute.org<mailto:ematson@broadinstitute.org>> Subject: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard Hi Dr. Jacobson, I hope you're doing well! I wanted to reach out because I am looking to recruit two Computational Chemists and a Cheminformatician to join the Center for the Development of Therapeutics (CDoT) modeling group at the Broad Institute and would love to tap your network! These roles will play a critical role in supporting medicinal chemistry efforts to advance current therapeutic projects within CDoT through structure-based and ligand-based modeling approaches. Take a look at the exciting pipeline of projects we are working on: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org… <https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> Here are the links to the job descriptions: https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw… <https://urldefense.proofpoint.com/v2/url?u=https-3A__broadinstitute.wd1.myw…> Please let me know if you have any postdocs in your program that would be interested in one of these roles. I am happy to connect you with our recruiter, Emily Matson, to fill in the details - she can be reached at ematson(a)broadinstitute.org<mailto:ematson@broadinstitute.org>. Let me know if you have any questions and many thanks! Best, AJ Working at CDoT<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> - Broad Institute of MIT & Harvard Broadminded Blog: Alisha Caliman cuts across disciplines as a computational chemist<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> CDoT Publications<https://urldefense.proofpoint.com/v2/url?u=https-3A__www.broadinstitute.org…> - CDoT's scientific leadership has an average of 15 years of Drug Discovery career experience and have advanced 32 compounds into the clinic. Together, they lead an organization of 80 research scientists and associates, 60% of whom have doctorates in relevant fields or areas of expertise. Arthur J Campbell, Ph.D. Group Leader, Senior Computational Chemist I _________________________________________ The Broad Institute of MIT and Harvard Center for the Development of Therapeutics Stanley Center for Psychiatric Research 415 Main Street, Cambridge, MA 02142 Tel 1-617-714-7372 Email ArthurC(a)BroadInstitute.org<mailto:ArthurC@BroadInstitute.org> https://urldefense.proofpoint.com/v2/url?u=http-3A__www.BroadInstitute.org&… <https://urldefense.proofpoint.com/v2/url?u=http-3A__www.BroadInstitute.org&…>

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[Compbio-allhands] Fwd: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard
by Brian Shoichet 20 Jun '19

20 Jun '19

FYI ---------- Forwarded message --------- From: AJ Campbell <arthurc(a)broadinstitute.org> Date: Thu, Jun 20, 2019 at 12:32 PM Subject: Computational Chemist and Cheminformatician Openings @ Broad Institute of MIT & Harvard To: <shoichet(a)cgl.ucsf.edu> Cc: Emily Matson <ematson(a)broadinstitute.org> Hi Dr. Shoichet, I hope you're doing well! I wanted to reach out because I am looking to recruit two Computational Chemists and a Cheminformatician to join the Center for the Development of Therapeutics (CDoT) modeling group at the Broad Institute and would love to tap your network! These roles will play a critical role in supporting medicinal chemistry efforts to advance current therapeutic projects within CDoT through structure-based and ligand-based modeling approaches. Take a look at the exciting pipeline of projects we are working on: https://www.broadinstitute.org/center-development-therapeutics/pipeline Here are the links to the job descriptions: https://broadinstitute.wd1.myworkdayjobs.com/broadinstitute_cdot/job/Cambri… https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Camb… https://broadinstitute.wd1.myworkdayjobs.com/en-US/broad_institute/job/Camb… Please let me know if you have any postdocs in your program that would be interested in one of these roles. I am happy to connect you with our recruiter, Emily Matson, to fill in the details - she can be reached at ematson(a)broadinstitute.org. Let me know if you have any questions and many thanks! Best, AJ *Working at CDoT <https://www.broadinstitute.org/center-development-therapeutics/working-cdot> - Broad Institute of MIT & Harvard* *Broadminded Blog:* *Alisha Caliman cuts across disciplines as a computational chemist* <https://www.broadinstitute.org/blog/alisha-caliman-cuts-across-disciplines-…> *CDoT Publications <https://www.broadinstitute.org/publications-list/1146>* *- CDoT's scientific leadership has an average of 15 years of Drug Discovery career experience and have advanced 32 compounds into the clinic. Together, they lead an organization of 80 research scientists and associates, 60% of whom have doctorates in relevant fields or areas of expertise.* *Arthur J Campbell, Ph.D.* Group Leader, Senior Computational Chemist I _________________________________________ *The Broad Institute of MIT and Harvard* Center for the Development of Therapeutics Stanley Center for Psychiatric Research 415 Main Street, Cambridge, MA 02142 Tel 1-617-714-7372 Email ArthurC(a)BroadInstitute.org www.BroadInstitute.org -- Brian Shoichet, Professor, UCSF *http://www.bkslab.org/contact.php <http://www.bkslab.org/contact.php>*

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[Compbio-allhands] Fwd: CADD job opportunity at NIBR-Emeryville (CA)
by Jacobson, Matt 12 Jun '19

12 Jun '19

— Matt Begin forwarded message: From: "Jansen, Johanna" <johanna.jansen(a)novartis.com<mailto:johanna.jansen@novartis.com>> Subject: CADD job opportunity at NIBR-Emeryville (CA) Date: June 11, 2019 at 3:46:39 PM PDT To: "matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>" <matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>> Dear Matt, I hope this message finds you well. I am writing to ask your help in recruiting. I have 2 openings in my group at NIBR-Emeryville (CA), one junior and one senior position. We are building up a department in Emeryville around our core expertise involving protein science, structure & biophysics, computational & medicinal chemistry. Our drug discovery focus will be on “targets in context”. The context for the targets includes other partner entities as well as the context of time (dynamics and kinetics). From a computational chemistry perspective, this means a focus on simulating large(r) multi-component complexes with the aim to understand mechanism and opportunity to modulate, including the design of novel therapeutics. From a computational medicinal chemistry perspective, a strategic focus will be on effective exploration of chemical space. This includes using multi-objective optimization combined with exceptional predictive modeling tools, generative chemistry, recommenders, and effective design cycles. I would very much appreciate your recommendations of potential candidates who have a passion for discovering drug candidates and who have skills in the area of macromolecular modeling & simulations and/or machine learning & data science. Experience in experimental structure & biophysics work or experimental medicinal chemistry would be an advantage (but not a requirement). Please let me know if you have anybody you would recommend I talk to for either the junior or the senior position. Feel free to share the link to the job description with potential candidates: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.novartis.com_caree… <https://urldefense.proofpoint.com/v2/url?u=https-3A__www.novartis.com_caree…> Thanks! Hanneke Johanna M. Jansen, PhD Head Computer-Aided Drug Discovery Emeryville Novartis Institutes for BioMedical Research Global Discovery Chemistry Emeryville 5300 Chiron Way CA 94608 Emeryville United States of America

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[Compbio-allhands] Fwd: CADD job opportunity at NIBR-Emeryville (CA)
by Andrej Sali 12 Jun '19

12 Jun '19

> Begin forwarded message: > > From: "Jansen, Johanna" <johanna.jansen(a)novartis.com> > Subject: CADD job opportunity at NIBR-Emeryville (CA) > Date: June 11, 2019 at 3:53:36 PM PDT > To: "sali(a)salilab.org" <sali(a)salilab.org> > > Dear Andrej, > > I hope this message finds you well. I am writing to ask your help in recruiting. I have 2 openings in my group at NIBR-Emeryville (CA), one junior and one senior position. > > We are building up a department in Emeryville around our core expertise involving protein science, structure & biophysics, computational & medicinal chemistry. Our drug discovery focus will be on “targets in context”. The context for the targets includes other partner entities as well as the context of time (dynamics and kinetics). From a computational chemistry perspective, this means a focus on simulating large(r) multi-component complexes with the aim to understand mechanism and opportunity to modulate, including the design of novel therapeutics. From a computational medicinal chemistry perspective, a strategic focus will be on effective exploration of chemical space. This includes using multi-objective optimization combined with exceptional predictive modeling tools, generative chemistry, recommenders, and effective design cycles. > > I would very much appreciate your recommendations of potential candidates who have a passion for discovering drug candidates and who have skills in the area of macromolecular modeling & simulations and/or machine learning & data science. Experience in experimental structure & biophysics work or experimental medicinal chemistry would be an advantage (but not a requirement). Please let me know if you have anybody you would recommend I talk to for either the junior or the senior position. Feel free to share the link to the job description with potential candidates: > https://www.novartis.com/careers/career-search/job-details/269776BR <https://www.novartis.com/careers/career-search/job-details/269776BR> > > Thanks! > Hanneke > > > > Johanna M. Jansen, PhD > Head Computer-Aided Drug Discovery Emeryville > > T +1 510 879 9548 > Johanna.jansen(a)novartis.com <mailto:Johanna.jansen@novartis.com> > > Novartis Institutes for BioMedical Research > Global Discovery Chemistry > Emeryville > 5300 Chiron Way > CA 94608 Emeryville > United States of America

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