- compbio-allhands@cgl.ucsf.edu - RBVI Mailing Lists

[Compbio-allhands] Fwd: Faculty position in Theoretical Soft/Bio Physics
by Andrej Sali 20 Sep '13

20 Sep '13

-- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Department of Pharmaceutical Chemistry California Institute for Quantitative Biosciences University of California, San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org Begin forwarded message: > From: "Mossman, Kaspar" <kaspar.mossman(a)qb3.org> > Subject: FW: Faculty position in Theoretical Soft/Bio Physics > Date: September 20, 2013 12:02:52 PM PDT > To: "SALI, ANDREJ" <sali(a)salilab.org> > > Hi Andrej, could you forward this to anyone who might be interested? and maybe if you know of relevant faculty w/ similar labs to yours, you could tell me who they might be? > > Thanks! > > Kaspar > > -----Original Message----- > From: Nancy Forde [mailto:nforde@sfu.ca] > Sent: Friday, September 20, 2013 11:37 AM > To: Mossman, Kaspar > Subject: Faculty position in Theoretical Soft/Bio Physics > > Dear Kaspar, > > I hope this message finds you well. If you are able to pass on this message and attached ad for a faculty position here at SFU to interested parties (i.e., theorists) at QB3, that would be great. > > SFU Physics is hiring a theorist in soft condensed matter or biological Physics. We are excited to be growing our complement of researchers in this area, and to further strengthen our already strong international reputation. Please help us to find the best candidate possible by forwarding the attached ad to outstanding theorists who would be interested in moving to beautiful Vancouver, British Columbia! Details are also available online at http://www.physics.sfu.ca/news/newsitem?id=79. > > Best wishes, > Nancy > > > -- > Nancy Forde > Associate Professor > Department of Physics > Simon Fraser University > 8888 University Dr. > Burnaby, BC V5A 1S6 > -- > nforde(a)sfu.ca > 778-782-3161; 778-782-3592 (fax) > http://www.sfu.ca/fordelab >

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[Compbio-allhands] Monica's thesis talk
by Jacobson, Matt 13 Sep '13

13 Sep '13

Reminder: Please join for Monica's Thesis Seminar! Monica Tremont (Jacobson Lab) Multiscale Models for Microtubule Assembly and Cytoplasmic Crowding Friday Sept 13, 2pm in GH Auditorium

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[Compbio-allhands] Fwd: POSTDOC OPPORTUNITY-PLEASE DISTRIBUTE
by Jacobson, Matt 05 Sep '13

05 Sep '13

Begin forwarded message: From: "Zachow, Christine A." <zachow2(a)llnl.gov<mailto:zachow2@llnl.gov>> Subject: POSTDOC OPPORTUNITY-PLEASE DISTRIBUTE Date: September 4, 2013 11:31:45 AM PDT To: Undisclosed recipients:; POSTDOC OPPORTUNITY-PLEASE DISTRIBUTE Lawrence Livermore National Laboratory is currently accepting applications for its prestigious Lawrence Fellowship. Applications can be submitted through our website: https://fellowship.llnl.gov/ They must be completed no later than November 1, 2013. The Lawrence Livermore National Laboratory’s prestigious Lawrence Fellowship is once again soliciting applications from your most promising rising postdocs. The fellowship was established to provide outstanding postdocs an opportunity to pursue cutting-edge science and stimulate cross-fertilization of ideas. The successful candidates have freedom to pursue world-class research with ample resources to support their efforts. The Fellows will interact with scientists with a wide range of expertise. The Laboratory is committed to making their experience at LLNL positive and rewarding. This three-year fellowship is awarded only to candidates with exceptional talent, credentials, scientific track records, and potential for significant achievements. Typically, two to four awards are given each year. After their three-year term, the Fellows may consider any career options, including employment at the Laboratory. Fellows will propose original and independent research in one or more aspects of science relevant to the mission and goals of LLNL. Research areas may include: * Atmospheric Science * Engineering * Biology * Environmental Science * Chemistry * Geoscience * Applied Mathematics * Lasers * Computer Science * Materials Science * Energy * Physics Further information is available at https://fellowship.llnl.gov/. You may contact me at zachow2(a)llnl.gov<x-msg://70/zachow2@llnl.gov> if you have any questions. Christine Zachow Program Administrator Lawrence Fellow & Lawrence Scholar Programs Lawrence Livermore National Laboratory 7000 East Ave. L-19 Livermore, CA 94550 925-423-0633 -- Matthew P. Jacobson Professor, Department of Pharmaceutical Chemistry Department of Bioengineering and Therapeutic Sciences California Institute for Quantitative Biosciences Institute for Neurodegenerative Diseases Director, Graduate Group in Biophysics UCSF MC 2540 1700 4th St., Byers Hall, Room 408E San Francisco, CA 94158-2330 matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu> jacobsonlab.org<http://jacobsonlab.org>

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[Compbio-allhands] Fwd: Job Description
by Andrej Sali 12 Aug '13

12 Aug '13

-- Andrej Sali, Ph.D. Professor, Department of Bioengineering and Therapeutic Sciences Department of Pharmaceutical Chemistry California Institute for Quantitative Biosciences University of California, San Francisco UCSF MC 2552 Byers Hall Room 503B 1700 4th Street San Francisco, CA 94158-2330, USA Tel +1 (415) 514-4227; Fax +1 (415) 514-4231 Assistant: Ms. Hilary Mahon, hilary(a)salilab.org, Tel +1 (415)514-4228; Lab +1 (415) 514-4233, 4258 Email sali(a)salilab.org; Web http://salilab.org Begin forwarded message: > From: "Mark Smythe" <m.smythe(a)protagonist-inc.com> > Subject: Job Description > Date: August 8, 2013 10:23:35 PM PDT > To: "'Andrej Sali'" <sali(a)salilab.org>, "'Charles Craik'" <Charles.Craik(a)ucsf.edu> > > Hi Andrej and Charly > Attached is the job description with a shorter version embeeded in this email. > If you have any comments/ammendments please let me know. > I will submit it to the web sites Andrej mentioned. > Please feel free to distribute. > Thanks for your help. > Mark > > Protagonist Therapeutics - Molecular Modeller /Computational Chemist / Bioinformatician > > Organisational Environment > Protagonist Therapeutics (www.protagonist-inc.com) is a US biotechnology company dedicated to the discovery of disulfide-rich peptides as well differentiated orally active peptides against those targets/diseases for which suitable small molecule or biologic options are not available. > > The work will be carried out at Menlo Park, California, USA. > > DUTY STATEMENT > > Primary Purpose of Position > Protagonist Therapeutics is seeking a talented and highly motivated scientist to join the drug design group. The candidate will use proprietary molecular modeling tools in combination with existing commercial software packages to design new compounds and optimize existing compounds. Protagonist is pursing the development of orally stable peptide derivatives for gastrointestinal diseases. > > The successful candidate will have a PhD in computational chemistry, bioinformatics or related discipline. The candidate will have previous involvement in all elements of molecular design impacting on IND candidate generation and proven ability to enhance peptide stability and permeability. In addition, the candidate will be familiar with molecular recognition and improving potency, be familiar with accessing public domain sequence, function, and structural information, has knowledge of disulfide rich peptides, macrocyles, clustering algorithm, molecular modeling packages, scripting/programming languages, with a preference for C++ and has worked in a Linux environment. The candidate well versed of the relevant literature, and have demonstrated hands on experience in structure based design. At least three years of industry experience is desirable. > > Duties > Duties and responsibilities include, but are not to: > • To be responsible for the structure-based drug design of one or more targets > • To optimize affinity of peptide-derivatives whilst maintaining and optimizing oral stability features > • To have up to date knowledge of the literature of one or more target > • The use of drug-design tools such as database searching, docking, scoring etc for the structure-based design of biologically active molecules > • To interpret and to use structural data, biological assay data, stability data, mutagenesis data, sequencing data, pharmacological data etc in the design of biological active molecules > > Reporting Relationships > The position reports to Dr Mark Smythe, VP Technology and Alliances for Protagonist Therapeutics. > > SELECTION CRITERIA > > Qualifications > The candidate will hold a Ph.D. in bioinformatics, computational chemistry or molecular modelling or related discipline, with significant research experience. Experiences in enhancing peptide affinity, stability and oral stability are essential. Project planning and meeting deadlines is an absolute advantage. Moreover, proven capacity and knowledge in deriving SAR of hit and lead candidates is highly desirable. > > Knowledge and Skills/Experience > Essential > • PhD in computational chemistry, bioinformatics or related discipline is required > • Proven translational experience towards IND candidates > • Knowledge of disulfide rich peptides and macrocycles > • Knowledge and practical experience in improving stability of peptides and macrocyles > • Previous experience in clustering > • Ability to program, preferably in C/C++ > • Working experience with pharmacophores > • Previous experience in structure-based drug design > • Thorough understanding of molecular recognition > • Thorough understanding of the drug design literature > • To have experience in scaffold hopping and peptide/protein engineering > • Develop and maintain integrated chemoinformatic database/registry > > Desirable > • Previous experience in database searching and docking > • Understanding of scoring functions > • Understanding of sequence search/alignment (Blast) > • Knowledge of SQL and Oracle Database > > Personal Qualities > Essential > • Ability to work in an efficient and well organized manner > • Ability to work collaboratively with internal and external team colleagues > • Ability to work with minimal supervision > • Ability to adhere to specific work schedules and meet deadlines > • Methodical approach to problem solving > • Excellent written and verbal communication skills > • Excellent interpersonal skills > • Sound problem-solving skills > > Remuneration: Protagonist Therapeutics provides competitive salary packages commensurate to experience to ensure that we are able to hire the best people from around the world. > > Closing Date: 21st August, 2013 > > Applications are to be sent to: > Human Resource Consultant > Email: hr(a)protagonist-inc.com > > >

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[Compbio-allhands] Fwd: 3 postdoc positions available immediately
by Jacobson, Matt 07 Aug '13

07 Aug '13

Begin forwarded message: From: <ealexov(a)clemson.edu<mailto:ealexov@clemson.edu>> Subject: 3 postdoc positions available immediately Date: August 7, 2013 6:18:02 AM PDT To: Undisclosed recipients:; Dear Colleagues, Just a quick announcement: 3 postdoctoral fellowships are immediately available here in Clemson (see below and the attached PDF file). Please, forward the announcement to all interested parties. I apologize to multiple copies of the ad that you may receive. Thank you in advance, Emil ================== Three post-doctoral fellowships in Biology of Human Diseases The Departments of Biological Sciences, Genetics and Biochemistry, and Physics at Clemson University are seeking three exceptionally talented new investigators, who hold a PhD in relevant fields. This unique opportunity exists for PhD graduates and postdoctoral fellows with a special interest in "The biology of human diseases: mechanisms, diagnosis, and personalized medicine", who aspire to become tenure track faculty in the near future. The fellows will be mentored by NIH funded researchers and trained in writing successful research grants, management of budgets and running a laboratory. We are especially looking for a computational biophysicist (3D structure modeling, energy calculations, MD and in silico virtual screening), an experimental biochemist (molecular cloning and protein purification, protein stability, enzyme activity, binding efficiency, enzyme kinetics, and structural determination) and an experimental biologist (cell and molecular biology/zebrafish model). These positions are part of the "Biology of Human Diseases" initiative at Clemson University to understand the molecular basis of human diseases and will provide the opportunity to development a pipe-line for diagnostics and treatment of genetic disorders. Postdoctoral fellows will have access to excellent experimental facilities and a supercomputer cluster. These positions are intended to act as a springboard for fast-track tenure track faculty positions and accepted post-doctoral fellows are required to submit a NIH Pathway to Independence Award (K99/R00). The positions are for an initial period of one year with possible appointment for an additional two years depending on satisfactory progress. The postdoctoral fellows will also help to train students in the participating departments. A competitive stipend inclusive of benefits and funding for research are offered according to field and experience. Interested candidates should send their CV, a statement of research and career objectives, and the names of at least three references in a single PDF to the following faculty: 1) Computational Biophysicist: Prof. Emil Alexov (ealexov(a)clemson.edu<mailto:ealexov@clemson.edu>) 2) Experimental Biochemist: Prof. Weiguo Cao (wgc(a)clemson.edu<mailto:wgc@clemson.edu>) 3) Experimental Biologist: Prof. Susan Chapman (SCHAPM2(a)clemson.edu<mailto:SCHAPM2@clemson.edu>) All application material received by September 1, 2013 will receive guaranteed consideration; however, applications will be accepted and evaluated until the positions are filled. Matthew P. Jacobson Professor, Department of Pharmaceutical Chemistry Department of Bioengineering and Therapeutic Sciences California Institute for Quantitative Biosciences Institute for Neurodegenerative Diseases Director, Graduate Group in Biophysics UCSF MC 2540 1700 4th St., Byers Hall, Room 408E San Francisco, CA 94158-2330 matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu> jacobsonlab.org<http://jacobsonlab.org>

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[Compbio-allhands] Fwd: Postdoc in Computational GPCR Ligand Design
by Brian Shoichet 28 Jun '13

28 Jun '13

FYI ---------- Forwarded message ---------- From: "David E. Gloriam" <david.gloriam(a)sund.ku.dk> Date: Jun 28, 2013 5:13 AM Subject: Postdoc in Computational GPCR Ligand Design To: "shoichet(a)cgl.ucsf.edu" <shoichet(a)cgl.ucsf.edu> Dear Brian, I have a computational chemistry postdoc opening in my group ( http://ccl.net/cca/jobs/joblist/mess0027098.shtml) I would be most grateful if you could please forward this mail to any interested person in your own group or network, that you think may be interested in a GPCR ligand design postdoc in Europe. Best Regards, David David Gloriam | Associate Professor Department of Drug Design and Pharmacology Faculty of Health And Medical Sciences University of Copenhagen T +45 35 33 61 62 | M +46 70 31 48 390

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[Compbio-allhands] Fwd: Job Opening for a Computational Chemist
by Jacobson, Matt 14 Jun '13

14 Jun '13

-- Matt Sent from my iPhone Begin forwarded message: From: "Demeter, David (DA)" <dademeter(a)dow.com<mailto:dademeter@dow.com>> Date: June 14, 2013, 12:44:50 PM PDT To: "kschulte(a)ks.uiuc.edu<mailto:kschulte@ks.uiuc.edu>" <kschulte(a)ks.uiuc.edu<mailto:kschulte@ks.uiuc.edu>>, "rod(a)ysbl.york.ac.uk<mailto:rod@ysbl.york.ac.uk>" <rod(a)ysbl.york.ac.uk<mailto:rod@ysbl.york.ac.uk>>, "brookscl(a)umich.edu<mailto:brookscl@umich.edu>" <brookscl(a)umich.edu<mailto:brookscl@umich.edu>>, "william.jorgensen(a)yale.edu<mailto:william.jorgensen@yale.edu>" <william.jorgensen(a)yale.edu<mailto:william.jorgensen@yale.edu>>, "shoichet(a)cgl.ucsf.edu<mailto:shoichet@cgl.ucsf.edu>" <shoichet(a)cgl.ucsf.edu<mailto:shoichet@cgl.ucsf.edu>>, "alex_tropsha(a)unc.edu<mailto:alex_tropsha@unc.edu>" <alex_tropsha(a)unc.edu<mailto:alex_tropsha@unc.edu>>, "pearlman(a)mail.utexas.edu<mailto:pearlman@mail.utexas.edu>" <pearlman(a)mail.utexas.edu<mailto:pearlman@mail.utexas.edu>>, "toprea(a)salud.unm.edu<mailto:toprea@salud.unm.edu>" <toprea(a)salud.unm.edu<mailto:toprea@salud.unm.edu>>, "carlos.simmerling(a)sunysb.edu<mailto:carlos.simmerling@sunysb.edu>" <carlos.simmerling(a)sunysb.edu<mailto:carlos.simmerling@sunysb.edu>>, "merz(a)qtp.ufl.edu<mailto:merz@qtp.ufl.edu>" <merz(a)qtp.ufl.edu<mailto:merz@qtp.ufl.edu>>, "nathan.baker(a)pnnl.gov<mailto:nathan.baker@pnnl.gov>" <nathan.baker(a)pnnl.gov<mailto:nathan.baker@pnnl.gov>>, "maxb(a)unc.edu<mailto:maxb@unc.edu>" <maxb(a)unc.edu<mailto:maxb@unc.edu>>, "matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>" <matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu>>, "fetrowjs(a)wfu.edu<mailto:fetrowjs@wfu.edu>" <fetrowjs(a)wfu.edu<mailto:fetrowjs@wfu.edu>>, "ajain(a)jainlab.org<mailto:ajain@jainlab.org>" <ajain(a)jainlab.org<mailto:ajain@jainlab.org>>, "mgilson(a)ucsd.edu<mailto:mgilson@ucsd.edu>" <mgilson(a)ucsd.edu<mailto:mgilson@ucsd.edu>>, "jbriggs(a)uh.edu<mailto:jbriggs@uh.edu>" <jbriggs(a)uh.edu<mailto:jbriggs@uh.edu>>, "flbrown(a)chem.ucsb.edu<mailto:flbrown@chem.ucsb.edu>" <flbrown(a)chem.ucsb.edu<mailto:flbrown@chem.ucsb.edu>>, "carlsonh(a)umich.edu<mailto:carlsonh@umich.edu>" <carlsonh(a)umich.edu<mailto:carlsonh@umich.edu>>, "lybrand(a)structbio.vanderbilt.edu<mailto:lybrand@structbio.vanderbilt.edu>" <lybrand(a)structbio.vanderbilt.edu<mailto:lybrand@structbio.vanderbilt.edu>>, "madura(a)mail.cc.duq.edu<mailto:madura@mail.cc.duq.edu>" <madura(a)mail.cc.duq.edu<mailto:madura@mail.cc.duq.edu>>, "dmorikis(a)engr.ucr.edu<mailto:dmorikis@engr.ucr.edu>" <dmorikis(a)engr.ucr.edu<mailto:dmorikis@engr.ucr.edu>>, "pomes(a)sickkids.on.ca<mailto:pomes@sickkids.on.ca>" <pomes(a)sickkids.on.ca<mailto:pomes@sickkids.on.ca>>, "tps(a)pnl.gov<mailto:tps@pnl.gov>" <tps(a)pnl.gov<mailto:tps@pnl.gov>>, "Celia.Schiffer(a)umassmed.edu<mailto:Celia.Schiffer@umassmed.edu>" <Celia.Schiffer(a)umassmed.edu<mailto:Celia.Schiffer@umassmed.edu>>, "case(a)biomaps.rutgers.edu<mailto:case@biomaps.rutgers.edu>" <case(a)biomaps.rutgers.edu<mailto:case@biomaps.rutgers.edu>>, "pap4(a)uic.edu<mailto:pap4@uic.edu>" <pap4(a)uic.edu<mailto:pap4@uic.edu>>, "ramaro(a)mccammon.ucsd.edu<mailto:ramaro@mccammon.ucsd.edu>" <ramaro(a)mccammon.ucsd.edu<mailto:ramaro@mccammon.ucsd.edu>> Subject: Job Opening for a Computational Chemist Ladies & Gentlemen, Dow AgroSciences currently has a job opening for a Ph.D. computational chemist. An additional 2-5 years of post-doctoral and/or industrial experience in molecular modeling is preferred. If you know of anyone who is currently seeking such a position, I would appreciate it if you would pass along this information. We are currently collecting resume’s and would like to start phone interviews by mid July. A link to the job posting is included below. Thank you for your time. http://careers.dowagro.com/job/Indianapolis-Computational-Chemist-Discovery… Sincerely, David A. Demeter, Ph.D. Senior Research Scientist, R&D Chemistry / CAMD Dow AgroSciences LLC 9330 Zionsville Road, Bldg 306/D2-884 Indianapolis, IN 46268 Voice: 317-337-3413 Fax: 317-337-3215 E-mail: dademeter(a)dow.com<mailto:dademeter@dow.com> NOTICE: This e-mail message (including all attachments) from Dow AgroSciences LLC is for the sole use of the intended recipient(s). Any unauthorized review, use, disclosure or distribution is strictly prohibited. If you are not the intended recipient, please contact the sender by reply e-mail and destroy all copies of the original message and any attachments.

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[Compbio-allhands] Dan Tawfik Seminar Announcement
by Flowers, Nicole 11 Jun '13

11 Jun '13

Please join Patsy Babbitt and Jaime Fraser on Thursday, June 20, 2013 12:00 – 1:00 PM Byers Auditorium, Genentech Hall for a talk by visiting seminar speaker Dan Tawfik, PhD Professor, Weizmann Institute of Science, Israel Department of Biological Chemistry on Enzyme Mechanism and Evolution --- Joslyn Polzien Assistant to Drs. Patricia Babbitt & Tanja Kortemme Dept. of Bioengineering & Therapeutic Sciences University of California, San Francisco 8 AM – 12 PM: (415) 514-1214 1 PM – 5 PM: (415) 514-4861 joslyn.polzien(a)ucsf.edu<mailto:joslyn.polzien@ucsf.edu> Nicole Takesono Flowers CCB Graduate Program Assistant AMBER Software Administrator UCSF MC 2280 600 16th St. Genentech Hall Room 522 San Francisco, CA 94158-2517 Phone: (415) 502-6518 Fax: (415) 514-1546

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[Compbio-allhands] Fwd: Available Postdoctoral Positions in Computational Chemical Biology
by Jacobson, Matt 04 Jun '13

04 Jun '13

Begin forwarded message: From: David Minh <dminh(a)iit.edu<mailto:dminh@iit.edu>> Subject: Available Postdoctoral Positions in Computational Chemical Biology Date: June 4, 2013 9:40:56 AM PDT To: Undisclosed recipients:; Dear Colleagues, I am accepting applications for postdoctoral positions in my new research group at the Illinois Institute of Technology, located in Chicago. Please encourage interested and suitable candidates to apply. One position is available in Fall 2013 and potentially another in Summer 2014. Research will focus on developing and applying molecular docking algorithms based on implicit ligand theory, a new theoretical framework for binding free energies based on rigid receptor configurations (http://dx.doi.org/10.1063/1.4751284<http://link.aip.org/link/doi/10.1063/1.4751284>). Ideal candidates will have strong computer programming skills, a background in computational/theoretical chemistry or physics (especially statistical mechanics), and interest in chemical biology and drug discovery. A PhD is required prior to the start date. Interested candidates should submit a cover letter, CV, and contact information for 2-3 references to david.minh(a)iit.edu<mailto:david.minh@iit.edu>. For more information, see http://mccammon.ucsd.edu/~dminh/ Best regards, David Minh Matthew P. Jacobson Professor, Department of Pharmaceutical Chemistry Department of Bioengineering and Therapeutic Sciences California Institute for Quantitative Biosciences Institute for Neurodegenerative Diseases Director, Graduate Group in Biophysics UCSF MC 2540 1700 4th St., Byers Hall, Room 408E San Francisco, CA 94158-2330 matt.jacobson(a)ucsf.edu<mailto:matt.jacobson@ucsf.edu> jacobsonlab.org<http://jacobsonlab.org>

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[Compbio-allhands] Fwd: superior CADD candidates
by Brian Shoichet 22 May '13

22 May '13

Dear Colleagues, This may interest some of you. Brian ---------- Forwarded message ---------- From: Herbertz, Torsten <therbertz(a)formatherapeutics.com> Date: Wed, May 22, 2013 at 12:51 PM Subject: superior CADD candidates To: "shoichet(a)cgl.ucsf.edu" <shoichet(a)cgl.ucsf.edu>, " klebe(a)staff.uni-marburg.de" <klebe(a)staff.uni-marburg.de>, " klebe(a)mailer.uni-marburg.de" <klebe(a)mailer.uni-marburg.de> Dear Prof. Shoichet & Klebe,**** ** ** I am reaching out to ask for your help in identifying exceptional candidates for open CADD positions at Forma Therapeutics ( http://formatherapeutics.com/) in the Boston area & making you aware that we would consider highly recommended post-docs in your labs.**** I made your acquaintance all the way back in 2002 at the Erice Gene-to-drugs xray crystallography conference and we have encountered each other on numerous occasions like the CADD GRC. Furthermore, I have been following your published work with much interest. Your laboratories produce very important results and insights that I attempt to apply & adapt to my own work, particularly here at Forma, where I have the privilege of leading a growing CompChem group (with 5 current members).**** We are mostly interested in candidates who have demonstrated small molecule drug discovery experience, a very sound understanding of medicinal chemistry and how to work with medchemists. Furthermore, good organic chemistry & biophysical chemistry are more important than method development, chemoinformatics, ….**** Forma is an oncology-focused relatively young (~5 years) and small (~110 people) company located in Watertown, MA.**** We are interested in many molecular target classes relevant to cancer biology, including cancer metabolism, epigenetics, protein-protein interactions and protein homeostasis to name a few.**** Computational chemistry is an integral part of our discovery paradigm; we generally only work on structure-enabled targets. Every project team includes a compchemists, who is invested as much as medicinal chemists, biologist and biochemists. In general, we follow two strategies in parallel: lead identification and chemical biology - in essence finding a tool compound for target validation. The hope is to push interesting chemical matter as far as we can toward pre-clinical development.**** This is a brief & simplified introduction to Forma and I hope that it convinces you that Forma is an exciting place to do drug discovery.**** I hope that you can provide interesting candidate leads for me to follow up. **** Any assistance that you can extend is deeply appreciated.**** ** ** Best regards,**** ** ** Torsten Herbertz, PhD**** Principal Scientist**** ** ** Forma Therapeutics, Inc.**** 500 Arsenal Street, Suite 100**** Watertown, MA 02472**** Email: therbertz(a)formatherapeutics.com <dmillan(a)formatherapeutics.com>**** Office: +1-857-209-2327**** www.formatherapeutics.com**** [image: Description: cid:image001.jpg@01CA92A2.4F452810]**** ** ** -- Brian Shoichet Professor University of California, San Francisco Dept. of Pharmaceutical Chemistry phone: 415-514-4126; fax: 415-514-4260 http://shoichetlab.compbio.ucsf.edu

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